Is the use of autologous platelet-rich plasma gels in gynecologic, cardiac, and general, reconstructive surgery beneficial?
| Autor: | Maarten M. Hoogbergen, Ignace H.J.T. de Hingh, Gust van Monftort, Peter A.M. Everts, Tjaarda A.Weber, Roger J.J. Devilee |
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| Rok vydání: | 2010 |
| Předmět: |
Chronic wound
Platelet-Derived Growth Factor Reconstructive surgery medicine.medical_specialty Pathology Wound Healing business.industry Angiogenesis Platelet-Rich Plasma Pharmaceutical Science Chemotaxis Fibrin Tissue Adhesive Plastic Surgery Procedures Extracellular matrix Platelet degranulation medicine Animals Humans Platelet medicine.symptom business Wound healing Biotechnology |
| Zdroj: | Current pharmaceutical biotechnology. 13(7) |
| ISSN: | 1873-4316 |
| Popis: | Tissue repair at wound sites begins with clot formation, and subsequently platelet degranulation with the release of platelet growth factors, which are necessary and well-regulated processes to achieve wound healing. Platelet-derived growth factors are biologically active substances that enhance tissue repair mechanisms, such as chemotaxis, cell proliferation, angiogenesis, extracellular matrix deposition, and remodeling. This review describes the biological background and results on the topical use of autologous platelet-rich plasma and platelet gel in gynecologic, cardiac, and general surgical procedures, including chronic wound management and soft-tissue injuries. |
| Databáze: | OpenAIRE |
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