LRRK2 G2385R and R1628P mutations are associated with an increased risk of Parkinson's disease in the Malaysian population
| Autor: | Gaik Bee Eow, Yi Zhao, Thien T hien Lim, Yip B oon Chong, Shelisa Tey, Eng-King Tan, Shanthi Viswanathan, Zariah Abdul Aziz, Azlina Ahmad-Annuar, Chong T in Tan, Aroma Agape Gopalai, Santhi Datuk Puvanarajah, Ai H uey Tan, Norlinah Mohamed Ibrahim, Jing Y i Chua, Irene Looi, Li P ing Tan, Soo K un Lim, Shen-Yang Lim |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Parkinson's disease Article Subject lcsh:Medicine Locus (genetics) Disease Biology Protein Serine-Threonine Kinases Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology Malaysian population Asian People Internal medicine medicine Humans Genetic Predisposition to Disease Aged Genetics General Immunology and Microbiology lcsh:R Case-control study Malaysia Parkinson Disease General Medicine Middle Aged medicine.disease LRRK2 Increased risk Case-Control Studies North african Female Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2014 (2014) |
| ISSN: | 2314-6141 |
| Popis: | TheLRRK2gene has been associated with both familial and sporadic forms of Parkinson’s disease (PD). The G2019S variant is commonly found in North African Arab and Caucasian PD patients, but this locus is monomorphic in Asians. The G2385R and R1628P variants are associated with a higher risk of developing PD in certain Asian populations but have not been studied in the Malaysian population. Therefore, we screened the G2385R and R1628P variants in 1,202 Malaysian subjects consisting of 695 cases and 507 controls. The G2385R and R1628P variants were associated with a 2.2-fold (P=0.019) and 1.2-fold (P=0.054) increased risk of PD, respectively. Our data concur with other reported findings in Chinese, Taiwanese, Singaporean, and Korean studies. |
| Databáze: | OpenAIRE |
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