Immunohistochemical demonstration of chromogranin A, chromogranin B, and secretoneurin in primary non-small-cell carcinomas of the lung
| Autor: | Birgit Kunk, Barbara Dockhorn-Dworniczak, Gregor Mikuz, Werner Böcker, Dietmar Öfner, Kurt Werner Schmid, Reiner Fischer-Colbrie, M. Tötsch |
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| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Lung biology Secretoneurin Endocrinology Diabetes and Metabolism Large cell Chromogranin A General Medicine medicine.disease Pathology and Forensic Medicine Endocrinology medicine.anatomical_structure biology.protein medicine Carcinoma Adenocarcinoma Immunohistochemistry Antibody |
| Zdroj: | Endocrine pathology. 5(4) |
| ISSN: | 1559-0097 |
| Popis: | Fifty-three primary non-small-cell lung carcinomas (NSCLC) were immunohistochemically investigated with antibodies against chromogranin A, chromogranin B, and ecretoneurin. All 3 peptides were focally immunolocalized in 3 of 25 adenocarcinomas and in 2 of 6 large-cell anaplastic carcinomas in more than 20% of tumor cells. Two of 15 squamous-cell carcinomas showed chromogranin B reactivity in more than 20% of tumor cells. Neuroendocrine (NE) differentiation was also demonstrated in lymphnode metastases of large-cell anaplastic carcinomas, in 1 adenocarcinoma, and in 1 squamous-cell carcinoma, with NE differentiation of the respective primary tumors. All tumors with NE differentiation exhibited (large cell) anaplastic tumor areas. We conclude that NE differentiation should be immunohistochemically proven or excluded, particularly in NSCLC with anaplastic components. Chromogranin B and secretoneurin are proposed as useful additional neuroendocrine markers for demonstration of NE differentiation in lung carcinomas. |
| Databáze: | OpenAIRE |
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