Graft-versus-host reaction in 3 adult leukaemia patients after transfusion of blood cell products
| Autor: | K.-O. Söderström, H. Korvenranta, Auli Toivanen, J. L. Kalliomäki, J. Nikoskelainen, A. Rajamäki, L. Meurman |
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| Rok vydání: | 1983 |
| Předmět: |
Male
medicine.medical_specialty Enlarged liver Neutropenia Adolescent Prednisolone Graft vs Host Disease Autopsy Bone Marrow Aplasia Blood cell hemic and lymphatic diseases Antineoplastic Combined Chemotherapy Protocols medicine Leukocytes Humans Thioguanine Cyclophosphamide medicine.diagnostic_test business.industry Daunorubicin Cytarabine Transfusion Reaction Hematology Middle Aged medicine.disease Surgery Pulmonary embolism Leukemia Myeloid Acute medicine.anatomical_structure Methotrexate Vincristine Skin biopsy Prednisone medicine.symptom Liver function tests business |
| Zdroj: | Scandinavian journal of haematology. 31(5) |
| ISSN: | 0036-553X |
| Popis: | We describe 3 cases of acute graft-versus-host (GVH) disease in patients with acute myeloid leukaemia following transfusions taken from non-HLA-identical healthy donors. The leucocyte transfusions were given because of severe bone marrow aplasia and granulocytopenia following leukaemia induction treatment. The first patient had an acute GVH reaction with an erythrodermia-like skin reaction all over and associated with severe abdominal cramping, enlarged liver and pathological liver function tests. The second patient had a relatively mild skin reaction and enlarged liver. Both died of severe pulmonary infection. The third patient also had a mild skin reaction and enlarged liver. He died of pulmonary embolism. The diagnosis of GVH of the latter 2 cases was made on skin biopsy. The autopsy samples revealed in all cases a heavy lymphocytic infiltration of the kidneys and liver portal area. Until more precise guidelines can be established, irradiation of blood cell products given to patients with neutropenia due to leukaemia induction treatment should be considered. |
| Databáze: | OpenAIRE |
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