Regulator of G Protein Signaling 5: A New Player in Vascular Remodeling
| Autor: | Mitali Manzur, Ruth Ganss |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
G protein
Angiogenesis Regulator Biology Regulator of G protein signaling medicine Humans Receptor RGS2 Evidence-Based Medicine Neovascularization Pathologic Hemodynamics Atherosclerosis Cell biology medicine.anatomical_structure Cardiovascular Diseases Vasoconstriction Hypertension Blood Vessels Vascular Resistance Pericyte Signal transduction Pericytes Cardiology and Cardiovascular Medicine RGS Proteins Signal Transduction |
| Zdroj: | Trends in Cardiovascular Medicine. 19:26-30 |
| ISSN: | 1050-1738 |
| DOI: | 10.1016/j.tcm.2009.04.002 |
| Popis: | Regulators of G protein signaling (RGS) proteins are important modulators of G protein-coupled receptors and, therefore, critical for cardiovascular functions. One family member, RGS5, has recently been identified as a key regulator of vascular remodeling and pericyte maturation in tumors. Here, we discuss a potential role for RGS5 and its relatives, RGS2 and 4, within the cardiovascular system. Insights into RGS5 signaling are likely to be highly significant for vascular pathologies such as hypertension, atherosclerosis, and angiogenesis. |
| Databáze: | OpenAIRE |
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