The Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice

Autor: Irfan Ullah, Guillaume Beaudoin-Bussières, Kelly Symmes, Marc Cloutier, Eric Ducas, Alexandra Tauzin, Annemarie Laumaea, Michael W. Grunst, Katrina Dionne, Jonathan Richard, Philippe Bégin, Walther Mothes, Priti Kumar, Renée Bazin, Andrés Finzi, Pradeep D. Uchil
Rok vydání: 2022
Předmět:
Zdroj: Cell reports. Medicine.
ISSN: 2666-3791
Popis: COVID-19 convalescent plasmas (CCPs) are chosen for plasma therapy based on neutralizing titers and anti-Spike immunoglobulin levels. However, CCP characteristics that promote SARS-CoV-2 control are complex and incompletely defined. Using an in vivo imaging approach, we demonstrate that CCPs with low neutralizing (ID
Databáze: OpenAIRE