The association of living donor source with patient and graft survival among kidney transplant recipients in the ERA-EDTA Registry – a retrospective study
Autor: | Julia Kerschbaum, Samar Abd ElHafeez, Marlies Noordzij, Ziad A. Massy, James G. Heaf, Kitty J Jager, Fernanda Ortiz, Torbjörn Lundgren, Anneke Kramer, Emilie Savoye, Mustafa Arici, Frederic Collart, Runolfur Palsson, Anna Varberg Reisæter, José Maria Abad Diez, Samira Bell, Carmen Santiuste de Pablos |
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Přispěvatelé: | HUS Abdominal Center, Clinicum, Helsinki University Hospital Area, Medical Informatics, APH - Aging & Later Life, APH - Quality of Care, APH - Global Health, APH - Methodology, ACS - Pulmonary hypertension & thrombosis |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Adult
Graft Rejection medicine.medical_specialty graft survival kidney transplantation 030230 surgery 03 medical and health sciences 0302 clinical medicine AGE patient survival Clinical Research Internal medicine medicine Living Donors Humans Registries Kidney transplantation Edetic Acid Retrospective Studies Transplantation Kidney business.industry Proportional hazards model RENAL-TRANSPLANTATION living donation Confounding Hazard ratio Graft Survival donor source Retrospective cohort study Original Articles medicine.disease 3126 Surgery anesthesiology intensive care radiology Confidence interval medicine.anatomical_structure surgical procedures operative EXPERIENCE 030211 gastroenterology & hepatology Graft survival Original Article business |
Zdroj: | Zaguán: Repositorio Digital de la Universidad de Zaragoza Universidad de Zaragoza Transplant International Abd ElHafeez, S, Noordzij, M, Kramer, A, Bell, S, Savoye, E, Abad Diez, J M, Lundgren, T, Reisæter, A V, Kerschbaum, J, Santiuste de Pablos, C, Ortiz, F, Collart, F, Palsson, R, Arici, M, Heaf, J G, Massy, Z A & Jager, K J 2021, ' The association of living donor source with patient and graft survival among kidney transplant recipients in the ERA-EDTA Registry – a retrospective study ', Transplant International, vol. 34, no. 1, pp. 76-86 . https://doi.org/10.1111/tri.13759 Transplant international, 34(1), 76-86. Wiley-Blackwell Zaguán. Repositorio Digital de la Universidad de Zaragoza instname |
ISSN: | 0934-0874 |
Popis: | In this study we aimed to compare patient and graft survival of kidney transplant recipients who received a kidney from a living-related donor (LRD) or living-unrelated donor (LUD). Adult patients in the ERA-EDTA Registry who received their first kidney transplant in 1998-2017 were included. Ten-year patient and graft survival were compared between LRD and LUD transplants using Cox regression analysis. In total, 14 370 patients received a kidney from a living donor. Of those, 9212 (64.1%) grafts were from a LRD, 5063 (35.2%) from a LUD and for 95 (0.7%), the donor type was unknown. Unadjusted five-year risks of death and graft failure (including death as event) were lower for LRD transplants than for LUD grafts: 4.2% (95% confidence interval [CI]: 3.7-4.6) and 10.8% (95% CI: 10.1-11.5) versus 6.5% (95% CI: 5.7-7.4) and 12.2% (95% CI: 11.2-13.3), respectively. However, after adjusting for potential confounders, associations disappeared with hazard ratios of 0.99 (95% CI: 0.87-1.13) for patient survival and 1.03 (95% CI: 0.94-1.14) for graft survival. Unadjusted risk of death-censored graft failure was similar, but after adjustment, it was higher for LUD transplants (1.19; 95% CI: 1.04-1.35). In conclusion, patient and graft survival of LRD and LUD kidney transplant recipients was similar, whereas death-censored graft failure was higher in LUD. These findings confirm the importance of both living kidney donor types. |
Databáze: | OpenAIRE |
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