Effect of bromfenac ophthalmic solution on ocular inflammation following cataract surgery
| Autor: | Satoshi Kato, Takashi Miyai, Ryohei Nejima, Masaru Miyanaga, Kazunori Miyata, Yoko Maruyama |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Intraocular pressure genetic structures medicine.medical_treatment Anti-Inflammatory Agents Visual Acuity Intraocular lens Cataract Extraction Betamethasone Macular Edema Aqueous Humor Cornea Benzophenones Lens Implantation Intraocular Ophthalmology medicine Humans Postoperative Period Macular edema Intraocular Pressure Aged Aged 80 and over Endophthalmitis business.industry Anti-Inflammatory Agents Non-Steroidal Endothelium Corneal General Medicine Phacoemulsification Middle Aged Cataract surgery medicine.disease eye diseases Surgery Treatment Outcome medicine.anatomical_structure Drug Therapy Combination Female Bromfenac sense organs Ophthalmic Solutions business Tomography Optical Coherence Bromobenzenes medicine.drug |
| Zdroj: | Acta Ophthalmologica. 87:300-305 |
| ISSN: | 1755-3768 1755-375X |
| DOI: | 10.1111/j.1755-3768.2008.01433.x |
| Popis: | Purpose: This study compared the post-cataract surgery anti-inflammatory effects of topical treatment with 0.1% bromfenac, 0.1% betamethasone or both on postoperative anterior chamber inflammation and corneal swelling. Methods: Seventy-two patients with no eye disease other than cataract were enrolled in a prospective, randomized study to undergo phacoemulsification combined with intraocular lens implantation. After cataract surgery, patients were randomized to treatment with bromfenac, betamethasone or both agents. Twenty-five eyes were assigned to bromfenac, 23 to betamethasone and 24 to the combined treatment group. Inflammatory reactions in the anterior chamber were measured with laser flare photometry preoperatively and at 1 and 3 days, 1 and 2 weeks, and 1 and 2 months postoperatively. Intraocular pressure (IOP) and corneal thickness were measured at the same time-points. Best corrected visual acuity (BCVA) was measured preoperatively and at 2 days, 1 and 2 weeks, and 1 and 2 months postoperatively. Specular microscope endothelial photography of the central region of the cornea was performed preoperatively and at 3 months after surgery. Results: There were no significant differences among the bromfenac, betamethasone and combined treatment groups in BCVA, IOP, aqueous flare or corneal thickness. Cystoid macular oedema was present in one eye treated with betamethasone. Conclusions: There were no significant differences in anti-inflammatory effects among the three treatments. These findings suggest that bromfenac is as effective as betamethasone in minimizing inflammatory reactions after cataract surgery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|