Impact of age of transfused blood on cerebral oxygenation in male patients with severe traumatic brain injury*
| Autor: | Victoria Arellano-Orden, Antonio Puppo-Moreno, Antonio Marín-Caballos, Francisco Murillo-Cabezas, Ana Marín, Manuel Muñoz-Gómez, Carmen Ferrándiz-Millón, J.M. Flores-Cordero, Rosario Amaya-Villar, Santiago R. Leal-Noval |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Resuscitation Time Factors Traumatic brain injury Central nervous system Critical Care and Intensive Care Medicine Blood cell Trauma Centers Intensive care medicine Humans Prospective Studies business.industry Brain Oxygenation Hypoxia (medical) medicine.disease Oxygen Red blood cell medicine.anatomical_structure Blood Preservation Brain Injuries Anesthesia medicine.symptom Erythrocyte Transfusion business |
| Zdroj: | Critical Care Medicine. 36:1290-1296 |
| ISSN: | 0090-3493 |
| DOI: | 10.1097/ccm.0b013e3181692dfc |
| Popis: | Prolonged erythrocyte storage time might reduce the efficacy of transfusion. In this study, the effects of transfusion of erythrocytes with four different storage periods (10 days, n = 18; 10-14 days, n = 15; 15-19 days, n = 17; and19 days, n = 16 patients) on brain tissue oxygen tension (PtiO2) in stable male patients with severe traumatic brain injury were investigated during a 24-hr follow-up period.Prospective, observational study.Neurotrauma critical care unit of a university hospital.Sixty-six male, nonbleeding, hemodynamically stable anemic patients (hemoglobin95 g/L) with Glasgow Coma Scale score9.None.PtiO2, cerebral perfusion pressure, mean arterial pressure, intracranial pressure, peripheral oxygen saturation, CO2 pressure at the end of expiration, and intracerebral temperature were recorded in all patients at baseline, immediately after the completion of transfusion, and 1, 2, 3, 4, 5, 6, 12, and 24 hrs posttransfusion. All four groups were homogeneous with respect to multiple baseline variables, except for storage time of transfused erythrocytes (p.0001). There was a significant short-lasting (3-4 hrs) increase in PtiO2 values after transfusion of erythrocytes stored for10 days, 10-14 days, or 15-19 days, compared with those at baseline. In contrast, no significant changes in PtiO2 were observed after transfusion of erythrocytes stored19 days.Transfusion of erythrocytes increased cerebral oxygenation in patients with severe traumatic brain injury, except in those transfused with erythrocytes stored19 days. |
| Databáze: | OpenAIRE |
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