Disease activity and thromboembolic events in women with systemic lupus erythematosus with and without anti-phospholipid syndrome: users of the 52-mg levonorgestrel-releasing intrauterine system
| Autor: | Estephania Pignaton, Simone Appenzeller, Rafaella C Rebelo, Arlete Fernandes, Luis Bahamondes, M. Valeria Bahamondes, Lilian Tereza Lavras Costallat |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Disease status medicine.medical_specialty Levonorgestrel Disease activity Cohort Studies 03 medical and health sciences Young Adult 0302 clinical medicine Antiphospholipid syndrome Internal medicine Medicine Humans Lupus Erythematosus Systemic Generalized estimating equation Retrospective Studies 030219 obstetrics & reproductive medicine business.industry Medical record Intrauterine Devices Medicated Obstetrics and Gynecology Retrospective cohort study General Medicine medicine.disease Antiphospholipid Syndrome 030220 oncology & carcinogenesis Anti-Phospholipid Syndrome Female business medicine.drug |
| Zdroj: | Archives of gynecology and obstetrics. 299(6) |
| ISSN: | 1432-0711 |
| Popis: | The disease status and thromboembolic events in women with systemic lupus erythematosus (SLE), with and without anti-phospholipid syndrome (APS), were evaluated before and after placement of the 52-mg levonorgestrel-releasing intrauterine system (LNG-IUS). A retrospective cohort study, with review of medical records of SLE women, who received an LNG-IUS placement between January 2007 and December 2016, carried out at the University of Campinas Medical School, Brazil. The outcomes included the disease activity (SLEDAI-2K) and damage index scores (SLICC/ACR-DI) presented for each year of device use, as well as venous/arterial thrombotic events, insertion up to a median of 5 years. The author’s used χ2, Fisher’s exact and the Mann–Whitney tests for analysis and generalized estimating equations for score comparison. The study evaluated 46 women with SLE, 18 with and 28 without APS; the mean age (± standard deviation [SD]) was 31.8 (SD ± 8.3) years old. The length of follow-up after LNG-IUS placement was 5.6 (SD ± 2.7) and 4.1 (SD ± 2.3) years for the groups with and without APS, respectively. Comparison of the groups found that the SLEDAI and SLICC mean scores were low for both at baseline, without variations through the follow-up. After LNG-IUS placement, two women presented three thrombotic arterial events, and one of them died from causes unrelated to LNG-IUS use. Our results, although restricted, provide information to policymakers and health professionals that the use of a 52 mg LNG-IUS over a 5-year median did not increase disease activity or damage index scores among women with SLE, with and without APS. |
| Databáze: | OpenAIRE |
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