Oxidative stress and myocardial damage during elective percutaneous coronary interventions and coronary angiography. A comparison of blood-borne isoprostane and troponin release
Autor: | Heidi Brurok, Sigurd Gunnes, Kristian S. Bjerve, Rune Wiseth, Sissel Skarra, Per Jynge, Samar Basu, Kirsti Berg |
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Rok vydání: | 2004 |
Předmět: |
Adult
Male medicine.medical_specialty Angioplasty Balloon Laser-Assisted Percutaneous Isoprostane medicine.medical_treatment Myocardial Infarction medicine.disease_cause Coronary Angiography Dinoprost Biochemistry Antioxidants chemistry.chemical_compound Troponin T Internal medicine medicine Humans Vitamin E Angioplasty Balloon Coronary Vitamin A Aged Aged 80 and over biology medicine.diagnostic_test business.industry Percutaneous coronary intervention General Medicine Middle Aged Troponin Oxidative Stress C-Reactive Protein chemistry Conventional PCI Angiography biology.protein Cardiology Female business Oxidative stress Biomarkers |
Zdroj: | Free radical research. 38(5) |
ISSN: | 1071-5762 |
Popis: | The role of oxidative stress in clinical cardiology is still controversial. The aims of the present study were to examine if minor ischaemic episodes as may occur during elective percutaneous coronary intervention (PCI) induce oxidative stress and, eventually, if oxygen stress correlates with myocardial injury. Thirty eight and nine patients underwent PCI and diagnostic coronary angiography, respectively. Peripheral blood was sampled at different time points for plasma analyses of: 8-iso-PGF2alpha (free radical-mediated oxidative stress); 15-keto-dihydro-PGF2alpha (cyclooxygenase-mediated inflammation); troponin-T (myocardial injury); hsCRP, vitamin A and vitamin E; and, total antioxidants status (TAS). In both groups 8-iso-PGF2alpha increased transiently by approximately 80% (p0.001) during the procedure. There was a minor troponin-T release (p0.001) after PCI, but no correlation with 8-iso-PGF2alpha. Troponin-T did not increase after angiography. 15-keto-dihydro-PGF2alpha decreased by 50% after ended procedure, but increased by 100% after 24 h compared to baseline. hsCRP increased significantly (p0.001) from baseline to the next day in the PCI-group, but not in the angiography group. Vitamins and TAS decreased slightly after the procedures. It is concluded that a moderate oxidative stress was induced by both elective PCI and coronary angiography but that no correlation was found between oxidative stress and myocardial injury in this setting. This indicates that other mechanisms than ischaemia-reperfusion episodes caused an elevation in plasma isoprostane such like the injury at a vascular site mutual for both procedures. A secondary finding from the study was elevated markers of early inflammatory response, not only after PCI, but also after angiography. |
Databáze: | OpenAIRE |
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