Complexity of bone marrow hematopoietic stem cell niche
| Autor: | Shoichiro Takeishi, Paul S. Frenette, Noboru Asada |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Sympathetic Nervous System Stromal cell Hematopoietic stem cell niche Niche Bone Marrow Cells Biology Article 03 medical and health sciences Tumor Microenvironment medicine Animals Humans Stem Cell Niche Tumor microenvironment Endothelial Cells Hematopoietic stem cell Hematology Hematopoietic Stem Cells Hematopoiesis Cell biology Haematopoiesis Cell Transformation Neoplastic 030104 developmental biology medicine.anatomical_structure Gene Expression Regulation Hematologic Neoplasms Immunology Neoplastic Stem Cells Cytokines Bone marrow Stromal Cells Stem cell Signal Transduction |
| Zdroj: | Int J Hematol |
| ISSN: | 1865-3774 0925-5710 |
| DOI: | 10.1007/s12185-017-2262-9 |
| Popis: | Hematopoietic stem cells (HSCs) that produce a variety of hematopoietic lineage cells throughout the life reside in specialized microenvironment called “niche” in the bone marrow (BM) where they are tightly regulated. With the recent advances in experimental technologies enabling the selective deletion of molecules, various types of cells in the BM have been proposed to contribute to HSC niche activity. Among these are stromal cells closely associated with the vasculature. In this review, we provide an overview of recent advances in HSC niche research, and focus on the studies describing the functional roles of perivascular cells for HSC maintenance and mobilization. Not only for physiologic state, we also discuss the recent evidences suggesting the importance of microenvironment for emergence of malignant hematopoietic diseases. |
| Databáze: | OpenAIRE |
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