Impaired spatial performance in cerebellar-deficient Lurcher mice is not associated with their abnormal stress response

Autor: Jan Cendelin, Yaroslav Kolinko, Jan Tuma, Pascal Hilber, Dana Jelinkova
Přispěvatelé: Department of Pathological Physiology, Faculty of Medicine in Pilsen, Charles University, alej Svobody 1655/76, 323 00 Pilsen, Czech Republic, Laboratory of Neurodegenerative Disorders, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, alej Svobody 1655/76, 323 00 Pilsen, Czech Republic., Laboratory of Quantitative Histology, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Karlovarska 48, 301 66 Pilsen, Czech Republic, Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University, Karlovarska 48, 301 66 Pilsen, Czech Republic., Centre de Recherches sur les Fonctionnements et Dysfonctionnements Psychologiques (CRFDP), Institut de Recherche Interdisciplinaire Homme et Société (IRIHS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Laboratory of Neurodegenerative Disorders, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, alej Svobody 1655/76, 323 00 Pilsen, Czech Republic, Normandie Université (NU)-Normandie Université (NU)-Institut de Recherche Interdisciplinaire Homme et Société (IRIHS)
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Cognitive Neuroscience
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Lurcher
Morris water navigation task
[SHS.PSY]Humanities and Social Sciences/Psychology
Experimental and Cognitive Psychology
Water maze
Spatial memory
03 medical and health sciences
Behavioral Neuroscience
chemistry.chemical_compound
Mice
Mice
Neurologic Mutants
0302 clinical medicine
Corticosterone
Stress
Physiological
Adrenal Glands
Water environment
medicine
[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
Animals
Habituation
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
[SCCO.NEUR]Cognitive science/Neuroscience
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
Organ Size
030104 developmental biology
medicine.anatomical_structure
[SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis
chemistry
[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
Space Perception
[SCCO.PSYC]Cognitive science/Psychology
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Psychology
Neuroscience
030217 neurology & neurosurgery
Zona reticularis
Spatial Navigation
Zdroj: Neurobiology of Learning and Memory
Neurobiology of Learning and Memory, Elsevier, 2017, 140, pp.62-70. ⟨10.1016/j.nlm.2017.02.009⟩
ISSN: 1095-9564
1074-7427
Popis: International audience; Both humans and laboratory animals suffering from cerebellar lesions exhibit cognitive as well as many emotional and behavioral abnormalities. These latter have been already observed in the cerebellar mutant mice currently used to highlight some aspect of autism spectrum disorders. The aim of this study was to investigate the influence of cerebellar-related stress response abnormalities on spatial learning and memory. Cerebellar-deficient Lurcher mutant mice were exposed to water environment without active escape possibility and then tested for spatial learning in the Morris water maze. As a marker of stress intensity we measured corticosterone in urine. Finally, the volumes of individual components of the adrenal gland were estimated. Though having spatial navigation deficit in the water maze, Lurcher mice preserved a substantial residuum of learning capacity. Lurcher mutants had a higher increase of cor-ticosterone level after exposure to the water environment than wild type mice. We did not observe any decrease of this physiological stress marker between the start and the end of the spatial navigation task, despite significant improvement of behavioral performances. Furthermore, zona fasciculata and zona reticularis of the adrenal cortex as well as the adrenal medulla were larger in Lurcher mice, reflecting high stress reactivity. We conclude that for both genotypes water exposure was a strong stressor and that there was no habituation to the experiment independently to the increasing controllability of the stressor (e.g. ability to find the escape platform). Based on these findings, we suggest that the enhanced stress response to water exposure is not the main factor explaining the spatial deficits in these cerebellar mutant mice.
Databáze: OpenAIRE
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