The distribution of congenital anomalies within the VACTERL association among tumor necrosis factor antagonist-exposed pregnancies is similar to the general population
| Autor: | Crijns, Hubertina J. M. J., Jentink, Janneke, Garne, Ester, Gispen-de Wied, Christine C., Straus, Sabine M. J. M., de Jong-van den Berg, Lolkje T. W., Bakker, Marian |
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| Přispěvatelé: | Reproductive Origins of Adult Health and Disease (ROAHD), Medical Informatics |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Heart Defects Congenital Pathology medicine.medical_specialty Databases Factual Immunology Population Limb Deformities Congenital Anal Canal Kidney Cohort Studies Esophagus Rheumatology EUROCAT Pregnancy VATER ASSOCIATION medicine Immunology and Allergy Distribution (pharmacology) Humans Immunologic Factors education education.field_of_study SPECTRUM business.industry Obstetrics Tumor Necrosis Factor-alpha VACTERL ASSOCIATION Antagonist Infant Newborn Abnormalities Drug-Induced DEFECTS medicine.disease VACTERL association Spine Europe Trachea Anal atresia SAFETY Prenatal Exposure Delayed Effects BIRTH DEFECT Tumor necrosis factor alpha TUMOR NECROSIS FACTOR ANTAGONISTS Female business |
| Zdroj: | Crijns, H J M J, Jentink, J, Garne, E, Gispen-de Wied, C C, Straus, S M J M, de Jong-van den Berg, L T W & EUROCAT Working Group 2011, ' The distribution of congenital anomalies within the VACTERL association among tumor necrosis factor antagonist-exposed pregnancies is similar to the general population ', Journal of Rheumatology, vol. 38, no. 9, pp. 1871-4 . https://doi.org/10.3899/jrheum.101316 Journal of Rheumatology, 38(9), 1871-1874. J RHEUMATOL PUBL CO Journal of Rheumatology, 38(9), 1871-1874. Journal of Rheumatology |
| ISSN: | 0315-162X |
| DOI: | 10.3899/jrheum.101316 |
| Popis: | Objective.To compare the distribution of congenital anomalies within the VACTERL association (vertebral defects, anal atresia, cardiac, tracheoesophageal, renal, and limb abnormalities) between patients exposed to tumor necrosis factor-α (TNF-α) antagonist and the general population.Methods.Analysis for comparison of proportional differences to a previous publication between anomaly subgroups, according to subgroup definitions of the European Surveillance of Congenital Anomalies (EUROCAT), a population-based database.Results.Most EUROCAT subgroups belonging to the VACTERL association contained only one or 2 records of TNF-α antagonist exposure, so comparison of proportions was imprecise. Only the category “limb abnormalities” showed a significantly higher proportion in the general population.Conclusion.The high number of congenital anomalies belonging to the VACTERL association from a report of pregnancies exposed to TNF-α antagonists could not be confirmed using a population-based congenital anomaly database. |
| Databáze: | OpenAIRE |
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