Interphalangeal Osteoarthritis Radiographic Simplified (iOARS) score: a radiographic method to detect osteoarthritis of the interphalangeal finger joints based on its histopathological alterations
| Autor: | Josef S Smolen, Love Amoyo-Minar, Franz Kainberger, Tanja Stamm, G. Supp, Afschin Soleiman, K. Bobacz, Birgit Niederreiter, Stefanie Haider, Ilse-Gerlinde Sunk |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Intraclass correlation Radiography Immunology Osteoarthritis Severity of Illness Index General Biochemistry Genetics and Molecular Biology Rheumatology Interphalangeal osteoarthritis Finger Joint medicine Humans Immunology and Allergy Aged Aged 80 and over Observer Variation Orthodontics Receiver operating characteristic business.industry Osteophyte Reproducibility of Results Middle Aged medicine.disease Surgery Exact test Female business Interphalangeal Joint Hand osteoarthritis |
| Zdroj: | Annals of the Rheumatic Diseases. 73:1983-1989 |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/annrheumdis-2012-203117 |
| Popis: | Objective To develop a radiographic score for assessment of hand osteoarthritis (OA) that is based on histopathological alterations of the distal (DIP) and proximal (PIP) interphalangeal joints. Methods DIP and PIP joints were obtained from corpses (n=40). Plain radiographies of these joints were taken. Joint samples were prepared for histological analysis; cartilage damage was graded according to the Mankin scoring system. A 2×2 Fisher9s exact test was applied to define those radiographic features most likely to be associated with histological alterations. Receiver operating characteristic curves were analysed to determine radiographic thresholds. Intraclass correlation coefficients (ICC) estimated intra- and inter-reader variability. Spearman9s correlation was applied to examine the relationship between our score and histopathological changes. Differences between groups were determined by a Student9s t test. Results The Interphalangeal Osteoarthritis Radiographic Simplified (iOARS) score is presented. The score is based on histopathological changes of DIP and PIP joints and follows a simple dichotomy whether OA is present or not. The iOARS score relies on three equally ranked radiographic features (osteophytes, joint space narrowing and subchondral sclerosis). For both DIP and PIP joints, the presence of one x-ray features reflects interphalangeal OA. Sensitivity and specificity for DIP joints were 92.3% and 90.9%, respectively, and 75% and 100% for PIP joints. All readers were able to reproduce their own readings in DIP and PIP joints after 4 weeks. The overall agreement between the three readers was good; ICCs ranged from 0.945 to 0.586. Additionally, outcomes of the iOARS score in a hand OA cohort revealed a higher prevalence of interphalangeal joint OA compared with the Kellgren and Lawrence score. Conclusions The iOARS score is uniquely based on histopathological alterations of the interphalangeal joints in order to reliably determine OA of the DIP and PIP joints radiographically. Its high specificity and sensitivity together with the dichotomous approach renders the iOARS score reliable, fast to perform and easy to apply. This tool may not only be valuable in daily clinical practice but also in clinical and epidemiological trials. |
| Databáze: | OpenAIRE |
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