You Had Me at 'MAGIC'!: Four Barley MAGIC Populations Reveal Novel Resistance QTL for Powdery Mildew

Autor: Fluturë, Novakazi, Lene, Krusell, Jens Due, Jensen, Jihad, Orabi, Ahmed, Jahoor, Therése, Bengtsson, On Behalf Of The Ppp Barley Consortium
Rok vydání: 2020
Předmět:
0106 biological sciences
0301 basic medicine
Candidate gene
Linkage disequilibrium
Genetics and Breeding
Blumeria graminis f. sp. hordei
lcsh:QH426-470
Hordeum vulgare L.
linkage disequilibrium
multi-parent advanced generation inter-cross
Quantitative Trait Loci
Blumeria graminis
Quantitative trait locus
Genes
Plant
01 natural sciences
Polymorphism
Single Nucleotide
Chromosomes
Plant
Linkage Disequilibrium
Article
03 medical and health sciences
Ascomycota
Genetics
GWAS
Allele
Genetics (clinical)
Alleles
Crosses
Genetic
Genetic association
Disease Resistance
Plant Diseases
Plant Proteins
Principal Component Analysis
biology
multi-locus mixed linear model
Haplotype
food and beverages
Bayes Theorem
Hordeum
biology.organism_classification
lcsh:Genetics
Plant Breeding
030104 developmental biology
Haplotypes
Powdery mildew
010606 plant biology & botany
Genome-Wide Association Study
Zdroj: Genes
Genes, Vol 11, Iss 1512, p 1512 (2020)
Volume 11
Issue 12
ISSN: 2073-4425
Popis: Blumeria graminis f. sp. hordei (Bgh), the causal agent of barley powdery mildew (PM), is one of the most important barley leaf diseases and is prevalent in most barley growing regions. Infection decreases grain quality and yields on average by 30%. Multi-parent advanced generation inter-cross (MAGIC) populations combine the advantages of bi-parental and association panels and offer the opportunity to incorporate exotic alleles into adapted material. Here, four barley MAGIC populations consisting of six to eight founders were tested for PM resistance in field trials in Denmark. Principle component and STRUCTURE analysis showed the populations were unstructured and genome-wide linkage disequilibrium (LD) decay varied between 14 and 38 Mbp. Genome-wide association studies (GWAS) identified 11 regions associated with PM resistance located on chromosomes 1H, 2H, 3H, 4H, 5H and 7H, of which three regions are putatively novel resistance quantitative trait locus/loci (QTL). For all regions high-confidence candidate genes were identified that are predicted to be involved in pathogen defense. Haplotype analysis of the significant SNPs revealed new allele combinations not present in the founders and associated with high resistance levels.
Databáze: OpenAIRE
Externí odkaz: