Evolution of Serum Lipids and Lipoprotein (a) Levels in Epileptic Children Treated With Carbamazepine, Valproic Acid, and Phenobarbital
| Autor: | Javier Rodríguez-García, Manuel Castro-Gago, Santiago Rodríguez-Segade, Jesús Eirís-Puñal, Blanco-Barca Mo, Adela Urisarri-Ruiz de Cortázar, M I Novo-Rodríguez |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
030213 general clinical medicine medicine.medical_specialty Time Factors Adolescent Normal diet Blood lipids 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Child Lipoprotein cholesterol Valproic Acid Epilepsy biology business.industry Lipoprotein(a) Carbamazepine Lipids Diet Endocrinology Phenobarbital Pediatrics Perinatology and Child Health biology.protein Anticonvulsants Female lipids (amino acids peptides and proteins) Neurology (clinical) business 030217 neurology & neurosurgery Lipoprotein medicine.drug |
| Zdroj: | Journal of Child Neurology. 21:48-53 |
| ISSN: | 1708-8283 0883-0738 |
| DOI: | 10.1177/08830738060210011601 |
| Popis: | The concentration levels of serum lipids and lipoprotein (a) were measured in 20 children receiving carbamazepine, 25 children receiving valproic acid, and 5 children receiving phenobarbital at the following times: (1) during chronic treatment while eating a normal diet, (2) during chronic treatment while eating a low-fat diet (children treated with carbamazepine and phenobarbital with high levels of total choleserol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol), and (3) 3 months after the end of treatment with antiepileptic drugs. Patients during chronic treatment and eating a normal diet revealed significant changes in lipids, but when we reevaluated the groups of children treated with carbamazepine and phenobarbital when they were eating a low-fat diet and reevaluated the three groups of children 3 months after the end of treatment, a complete return to normal of all parameters was observed. These data demonstrate that the changes induced by these drugs are transient, reversible, and influenced by a low-fat diet. ( J Child Neurol 2006;21:48—53). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|