Detection of Agents which Interfere with the Immune Response

Autor:	George H. Hitchings, Samuel Bieber, Henry C. Nathan, Gertrude B. Elion
Rok vydání:	1961
Předmět:	Immune System Phenomena Immune system Screening test Immunity business.industry Immunology Humans Medicine business General Biochemistry Genetics and Molecular Biology
Zdroj:	Experimental Biology and Medicine. 107:796-799
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-107-26758
Popis:	SummaryA screening test is described for materials which suppress the immune response during its inductive phase. This test is based on the formation of hemagglutinins to sheep red blood cells in mice. 6-Mercap-topurine, 6-thioguanine and their S-imidazolyl derivatives, B.W. 57-322 and B.W. 57-323, show high activity.The authors wish to acknowledge their indebtedness to Dr. Robert Schwartz for the suggestion which stimulated this investigation, and to thank Dr. R. Y. Calne and Dr. A. W. Frisch for the opportunities to read their papers in advance of publication.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a92e4449c3a8b0ea0c1e68d4110479a https://doi.org/10.3181/00379727-107-26758 Zobrazit plný text záznamu