Stewart-Treves syndrome: an histogenetic (ultrastructural and immunohistological) study
| Autor: | G. Rigot-Muller, Jean Kanitakis, C. Marchand, A. Bendelac, Jean Thivolet |
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| Rok vydání: | 1986 |
| Předmět: |
Pathology
medicine.medical_specialty Histology Skin Neoplasms Antibodies Neoplasm Vimentin Dermatology Histogenesis Pathology and Forensic Medicine Agglutinin Antigen Keratin medicine Humans Stewart–Treves syndrome Mastectomy Aged chemistry.chemical_classification biology business.industry Lectin Lymphangiosarcoma Syndrome medicine.disease Microscopy Electron chemistry biology.protein Female Antibody business |
| Zdroj: | Journal of cutaneous pathology. 13(1) |
| ISSN: | 0303-6987 |
| Popis: | One case of the so-called „Stewart-Treves syndrome” (STS), appearing on a lymphoedomatous arm complicating radical mastectomy for brest cancer, was characterized electronmicroscopically and immunohistologically, in order to elucidate its disputed (epithelial vs endothelial) histogenesis. Epithelial and endothelial differentiation markers used comprised: antibodies against keratin, vimentin, factor VIII-related antigen (F VIII-RA), HLA-DR antigens and the lectin Ulex europeaus agglutinin 1 (UEA I). At the ultrastructural level, neoplastic cells were found to contain typical Weibel-Palade bodies, whereas by immunohistological techniques they proved to be keratin −negative/vimentin+, F VIII-RA +, UEAI+, HLA-DR+. These results rule out a possible epithelial differentiation and strongly favour an endothelial one for STS. |
| Databáze: | OpenAIRE |
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