Identification and management of Lynch syndrome in the Middle East and North African countries: outcome of a survey in 12 countries
| Autor: | Mary E. Velthuizen, Amal Abedrabbo, Demetra Georgiou, Ala I. Sharara, Keivan Majidzadeh-A, Carol Jabari, Laila Rifai, Andreas Hadjisavvas, Fahd Al-Mulla, Hans F. A. Vasen, Zeinab Ghorbanoghli, Rihab Ben Sghaier, Suzan M Talaat, Rania Abu Seir, Gurbankhan Muslumov, Wail Hammoudeh, Maria A. Loizidou, Hadia Ziada-Bouchaar, George Cortas, Berrin Tunca, Makia J. Marafie, Aysel Ahadova, Waseem Hamoudi, Ladan Goshayeshi, Marie-Pierre Buisine, Mohammad Sina |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
medicine.medical_specialty Azerbaijan Population Computer-assisted web interviewing DNA Mismatch Repair Health Services Accessibility 03 medical and health sciences Middle East 0302 clinical medicine Africa Northern Epidemiology Health care Genetics medicine Humans Genetic Testing North African countries Family history education Genetics (clinical) Genetic testing Amsterdam Criteria II Middle Eastern countries Colorectal cancer Lynch syndrome Family Health Population Density education.field_of_study medicine.diagnostic_test business.industry Genetic Services Colonoscopy medicine.disease Colorectal Neoplasms Hereditary Nonpolyposis Arabs Oncology 030220 oncology & carcinogenesis Family medicine Health Care Surveys Population Surveillance Cyprus Practice Guidelines as Topic 030211 gastroenterology & hepatology Original Article business |
| Zdroj: | Familial Cancer, 20, 215-221. SPRINGER Familial Cancer |
| Popis: | Background Lynch syndrome (LS), the most common inherited form of colorectal cancer (CRC), is responsible for 3% of all cases of CRC. LS is caused by a mismatch repair gene defect and is characterized by a high risk for CRC, endometrial cancer and several other cancers. Identification of LS is of utmost importance because colonoscopic surveillance substantially improves a patient’s prognosis. Recently, a network of physicians in Middle Eastern and North African (ME/NA) countries was established to improve the identification and management of LS families. The aim of the present survey was to evaluate current healthcare for families with LS in this region. Methods A questionnaire was developed that addressed the following issues: availability of clinical management guidelines for LS; attention paid to family history of cancer; availability of genetic services for identification and diagnosis of LS; and assessment of knowledge of LS surveillance. Members of the network and authors of recent papers on LS from ME/NA and neighbouring countries were invited to participate in the survey and complete the online questionnaire. Results A total of 55 individuals were invited and 19 respondents from twelve countries including Algeria, Azerbaijan, Cyprus, Egypt, Iran, Jordan, Kuwait, Lebanon, Morocco, Palestine, Tunisia, and Turkey completed the questionnaire. The results showed that family history of CRC is considered in less than half of the surveyed countries. Guidelines for the management of LS are available in three out of twelve countries. The identification and selection of families for genetic testing were based on clinical criteria (Amsterdam criteria II or Revised Bethesda criteria) in most countries, and only one country performed universal screening. In most of the surveyed countries genetic services were available in few hospitals or only in a research setting. However, surveillance of LS families was offered in the majority of countries and most frequently consisted of regular colonoscopy. Conclusion The identification and management of LS in ME/NA countries are suboptimal and as a result most LS families in the region remain undetected. Future efforts should focus on increasing awareness of LS amongst both the general population and doctors, and on the improvement of the infrastructure in these countries. |
| Databáze: | OpenAIRE |
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