Immune response in hormonally-induced prostatic hyperplasia in the dog
| Autor: | Jack A. Schalken, W. Mahapokai, Jan A. Mol, F. N. van Mil, T.S.G.A.M. van den Ingh, E. van Garderen, F.J. van Sluijs |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Pathology CD3 Complex medicine.drug_class Immunology Prostatic Hyperplasia Receptors Antigen B-Cell Urological oncology Inflammation Peripheral blood mononuclear cell Dogs Immune system Antigens CD Internal medicine medicine Animals Urologische oncologie Dog Diseases Estradiol General Veterinary biology business.industry Goats Prostate Hyperplasia medicine.disease Androgen Androstane-3 17-diol Mononuclear cell infiltration Phenotype Endocrinology biology.protein Rabbits medicine.symptom Antibody business Infiltration (medical) CD79 Antigens |
| Zdroj: | Veterinary Immunology and Immunopathology, 78, 3-4, pp. 297--303 Veterinary Immunology and Immunopathology, 78, 297--303 |
| ISSN: | 0165-2427 |
| DOI: | 10.1016/s0165-2427(01)00236-7 |
| Popis: | Item does not contain fulltext We induced prostatic enlargement in castrated dogs using either androgen alone or androgen combined with estrogen. In addition to previously reported hyperplastic changes, marked infiltration with immune effector cells was observed. This mononuclear cell infiltrate was phenotypically characterized using CD3 as pan T-lymphocyte marker, CD79 for B-lymphocytes, MAC378 for macrophages, and antibodies against kappa- and lambda-immunoglobulin (Ig) light chains for plasma cells. The majority of inflammatory cells (>80%) in the mononuclear infiltrates were T-lymphocytes and the numbers correlated with the degree of inflammation. The B-lymphocytes were found particularly in areas with marked follicular formation and diffuse infiltration, whereas there were only a few positive cells ( |
| Databáze: | OpenAIRE |
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