Cryoballoon Ablation for Pulmonary Vein Isolation in Patients With Persistent Atrial Fibrillation
| Autor: | Eduard Gorr, Oezlem Hengeoez, Christian Hoppe, Buelent Koektuerk, Ramazan G. Turan, Alexander Yang, Hikmet Yorgun, Marc Horlitz, Cem Hakan Turan, Paul M. Bansmann, Alina Dahmen |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Cryosurgery Pulmonary vein Electrocardiography Postoperative Complications Physiology (medical) Internal medicine Atrial Fibrillation Humans Medicine Outpatient clinic Sinus rhythm medicine.diagnostic_test business.industry Hazard ratio Atrial fibrillation Middle Aged medicine.disease Confidence interval Surgery Ostium Treatment Outcome Echocardiography Pulmonary Veins Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation: Arrhythmia and Electrophysiology. 8:1073-1079 |
| ISSN: | 1941-3084 1941-3149 |
| DOI: | 10.1161/circep.115.002776 |
| Popis: | Background— Data regarding the freedom from atrial fibrillation (AF) in the follow-up of persistent AF patients is limited. The second-generation cryoballoon has better cooling properties compared with first-generation cryoballon. In this study, we aimed to assess the medium-term efficacy of second-generation cryoballoon in patients with persistent AF. Methods and Results— A total of 100 patients (63±10 years, 80% male) with symptomatic persistent AF, despite ≥1 antiarrhythmic drug(s), who were scheduled for pulmonary vein isolation using second-generation cryoballoon were enrolled in this study. Follow-up was based on outpatient clinic visits, including Holter ECGs. Recurrence was defined as a symptomatic or documented arrhythmia episode of >30 seconds excluding a 3-month blanking period. As a result, 393 pulmonary veins (7 patients with common ostium) were successfully isolated. Mean procedural and fluoroscopy times were 96.2±21.3 and 19.7±6.7 minutes, respectively. Phrenic nerve palsy occurred in 3% (3/100) of the patients. At a mean follow-up duration of 10.6±6.3 months, 67% of the patients were in sinus rhythm. Stepwise multivariable Cox proportional hazard regression analysis showed that early AF recurrence (hazard ratio 3.83, 95% confidence interval 1.91–7.68, P Conclusions— Our findings indicated that second-generation cryoballoon use is associated with favorable outcomes in patients with persistent AF. Recurrence at blanking period was the only predictor of long-term AF recurrence. |
| Databáze: | OpenAIRE |
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