Dual-action penems and carbapenems
| Autor: | Joel Unowsky, Alfred John Corraz, Scott L. Dax, Rossman Pamela Loreen, N H Georgopapadakou, David L. Pruess, Rudolf L. Then, Norma K. Dunlap, Dennis D. Keith, Chung Chen Wei |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Carbamate
Bicyclic molecule Bacteria Chemistry Stereochemistry medicine.medical_treatment Biological activity Microbial Sensitivity Tests Anti-Bacterial Agents chemistry.chemical_compound Carbapenems Drug Discovery medicine Lactam Molecular Medicine Moiety Antibacterial activity Enone Antibacterial agent |
| Zdroj: | Journal of medicinal chemistry. 35(10) |
| ISSN: | 0022-2623 |
| Popis: | Two new series of dual-action antibacterial agents were synthesized in which penems and carbapenems were linked at the 2'-position to quinolones through either an ester or a carbamate moiety. Potent, broad-spectrum antibacterial activity was observed for both classes of compounds, indicative of a dual-mode of action. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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