Immunotherapy and Thyroid Dysfunction: Relevance to Nuclear Medicine
| Autor: | Amol Takalkar, Anil Ramachandran, Surender Arora, Juan S. Gomez, Maria Laura Gregorio |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
endocrine system
medicine.medical_specialty Lung Neoplasms endocrine system diseases medicine.medical_treatment Thyroid Gland Thyrotropin Gastroenterology Thyroiditis 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Thyroid dysfunction Internal medicine medicine Stage iib Humans Radiology Nuclear Medicine and imaging Aged business.industry Thyroid General Medicine Immunotherapy medicine.disease Small Cell Lung Carcinoma Thyroxine medicine.anatomical_structure Nivolumab 030220 oncology & carcinogenesis Female Non small cell Nuclear Medicine business Hormone |
| Zdroj: | Clinical nuclear medicine. 45(9) |
| ISSN: | 1536-0229 |
| Popis: | We report a case of a 66-year-old woman with small cell lung cancer (stage IIB, T2N1M0), who received immunotherapy with nivolumab monthly for 2 months and then presented with thyrotoxic symptoms associated with suppressed thyroid-stimulating hormone levels and elevated free thyroid hormone levels, although previous thyrotropin performed 1 month ago was normal. Thyroid uptake and scan demonstrated diffusely decreased uptake in both thyroid lobes. The 4-hour percentage uptake was 0.7%, and the 24-hour percentage uptake was 0.3%. This was followed by development of hypothyroidism within few weeks. Findings suggested drug-induced thyroiditis secondary to nivolumab therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|