Midlife stroke risk and cognitive decline: A 10-year follow-up of the Whitehall II cohort study
| Autor: | Eric J. Brunner, Archana Singh-Manoux, Sara Kaffashian, Séverine Sabia, Mika Kivimäki, Joël Ankri, Aline Dugravot |
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| Přispěvatelé: | Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Department of Epidemiology and Public Health, University College of London [London] (UCL), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Centre de Gérontologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Sainte Perine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), S.K. was funded by a doctoral grant from Region Ile-de-France. A.S.-M. was supported by a European Young Investigator Award from the European Science Foundation and the Na- tional Institute on Aging, National Institutes of Health (R01AG013196, R01AG034454). M.K. was supported by the Academy of Finland, the BUPA Foundation, the National Institutes of Health (R01HL036310, R01AG034454), and the Medical Research Council., SZTAJNBOK, Pascale, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2013 |
| Předmět: |
Gerontology
Male Aging Epidemiology Cognitive decline Cohort Studies 0302 clinical medicine Risk Factors MESH: Risk Factors Verbal fluency test 030212 general & internal medicine Stroke MESH: Cohort Studies Framingham Risk Score MESH: Middle Aged Health Policy Smoking MESH: Follow-Up Studies Middle Aged 3. Good health Cognitive test Framingham Stroke Risk Profile Psychiatry and Mental health Vascular risk factors Cardiovascular Diseases Female Psychology Cohort study MESH: Smoking MESH: Diabetes Mellitus Clinical Neurology Mid life MESH: Stroke 03 medical and health sciences Cellular and Molecular Neuroscience Developmental Neuroscience medicine Diabetes Mellitus Dementia Humans MESH: Humans MESH: Cardiovascular Diseases medicine.disease Confidence interval MESH: Male MESH: Cognition Disorders [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Neurology (clinical) Geriatrics and Gerontology Cognition Disorders MESH: Female 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Alzheimer's and Dementia Alzheimer's and Dementia, Elsevier, 2013, 9 (5), pp.572-9. ⟨10.1016/j.jalz.2012.07.001⟩ |
| ISSN: | 1552-5260 |
| DOI: | 10.1016/j.jalz.2012.07.001 |
| Popis: | Background: Stroke is associated with an increased risk of dementia. However, it is unclear whether risk of stroke in those free of stroke, particularly in nonelderly populations, leads to differential rates of cognitive decline. Our aim was to assess whether risk of stroke in mid life is associated with cognitive decline over 10 years of follow-up. Methods: We studied 4153 men and 1657women (mean age,55.6 years atbaseline) from the Whitehall II study, a longitudinal British cohort study. We used the Framingham Stroke Risk Profile (FSRP), which incorporates age, sex, systolic blood pressure, diabetes mellitus, smoking, prior cardiovascular disease, atrial fibrillation, left ventricular hypertrophy, and use of antihypertensive medication. Cognitive tests included reasoning, memory, verbal fluency, and vocabulary assessed three times over 10 years. Longitudinal associations between FSRP and its components were tested using mixed-effects models, and rates of cognitive change over 10 years were estimated. Results: Higher stroke risk was associated with faster decline in verbal fluency, vocabulary, and global cognition. For example, for global cognition there was a greater decline in the highest FSRP quartile (20.25 of a standard deviation; 95% confidence interval: 20.28 to 20.21) compared withthelowestriskquartile(P5.03).Noassociationwasobservedformemoryandreasoning.Ofthe individual components of FSRP, only diabetes mellitus was associated independently with faster cognitive decline (b 52 0.06; 95% confidence interval, 20.01 to 0.003; P 5.03). Conclusion: Elevated stroke risk at midlife is associated with accelerated cognitive decline over 10 years. Aggregation of risk factors may be especially important in this association. 2013 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. Thisisan openaccessarticleundertheCCBY-NC-NDlicense(http://creativecommons.org/licenses/by-nc-nd/3.0/). |
| Databáze: | OpenAIRE |
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