Alterations on peripheral blood B cell subsets induced by allergic rhinitis
| Autor: | Hélder Trindade, António Martinho, Rodrigo Nunes, Graça Loureiro, Maria Luísa Pais, Artur Paiva, António Segorbe-Luís, Celso Pereira, Ana Henriques |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Allergy Dermatophagoides pteronyssinus medicine.medical_treatment Immunology B-Lymphocyte Subsets Flow cytometry Pathogenesis Internal medicine medicine Animals Humans B cell Desensitization (medicine) Pharmacology medicine.diagnostic_test business.industry Immunotherapy Immunoglobulin E Flow Cytometry medicine.disease Rhinitis Allergic Isotype Rheumatology Immunoglobulin A medicine.anatomical_structure Immunoglobulin M Desensitization Immunologic Case-Control Studies Immunoglobulin G Leukocytes Mononuclear Female business |
| Zdroj: | Inflammation Research. 64:145-149 |
| ISSN: | 1420-908X 1023-3830 |
| Popis: | Objectives and design Here we evaluated whether allergic rhinitis to Dermatophagoides pteronyssinus induces alterations on circulating B cell subsets. Materials and methods Circulating B cell subsets and isotype expression on antigen-experienced B cells from allergic patients under conventional pharmacological treatment (NO-SIT, n = 15) and under subcutaneous immunotherapy (SCIT, n = 33), and non-allergic subjects (NC, n = 25) were analyzed by flow cytometry. Results In allergic patients, we found a significant decrease in IgM ? and IgG ? memory B cells and an increase in IgA ? memory B cells. Additionally, the numbers of circulating IgA ? plasmablasts in allergic patients were also increased, while those cells expressing IgM were reduced. Conclusions Allergic patients have a disturbed B cell subsets distribution which seems to underlie rhinitis pathogenesis and remain unchanged after SCIT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink