A Broad Application of CRISPR Cas9 in Infectious Diseases of Central Nervous System
| Autor: | Nicholas Ahye, Hassen S. Wollebo, Anna Bellizzi, Gauthami Jalagadugula |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
viruses Immunology Central nervous system Neuroscience (miscellaneous) Biology Bioinformatics Genome Article 03 medical and health sciences Human health 0302 clinical medicine Immune system Genome editing Central Nervous System Diseases CRISPR-Associated Protein 9 medicine Animals Humans Immunology and Allergy CRISPR Gene Editing Pharmacology Cas9 Genetic Therapy Alternative treatment 030104 developmental biology medicine.anatomical_structure CRISPR-Cas Systems 030217 neurology & neurosurgery |
| Zdroj: | J Neuroimmune Pharmacol |
| ISSN: | 1557-1904 1557-1890 |
| Popis: | Virus-induced diseases or neurological complications are huge socio-economic burden to human health globally. The complexity of viral-mediated CNS pathology is exacerbated by reemergence of new pathogenic neurotropic viruses of high public relevance. Although the central nervous system is considered as an immune privileged organ and is mainly protected by barrier system, there are a vast majority of neurotropic viruses capable of gaining access and cause diseases. Despite continued growth of the patient population and a number of treatment strategies, there is no successful viral specific therapy available for viral induced CNS diseases. Therefore, there is an urgent need for a clear alternative treatment strategy that can effectively target neurotropic viruses of DNA or RNA genome. To address this need, rapidly growing gene editing technology based on CRISPR/Cas9, provides unprecedented control over viral genome editing and will be an effective, highly specific and versatile tool for targeting CNS viral infection. In this review, we discuss the application of this system to control CNS viral infection and associated neurological disorders and future prospects. Graphical Abstract CRISPR/Cas9 technology as agent control over CNS viral infection. |
| Databáze: | OpenAIRE |
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