SK channels and the varieties of slow after-hyperpolarizations in neurons
Autor: | Fivos Vogalis, Barrie Lancaster, Johan F. Storm |
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Rok vydání: | 2003 |
Předmět: |
Neurons
Membrane potential Potassium Channels Small-Conductance Calcium-Activated Potassium Channels Chemistry General Neuroscience Cell Membrane Action Potentials Apamin Potassium channel SK channel Potassium Channels Calcium-Activated Protein Subunits chemistry.chemical_compound Slow afterhyperpolarization Animals Humans Calcium Calcium Signaling Neuroscience Ion channel |
Zdroj: | European Journal of Neuroscience. 18:3155-3166 |
ISSN: | 1460-9568 0953-816X |
Popis: | Action potentials and associated Ca2+ influx can be followed by slow after-hyperpolarizations (sAHPs) caused by a voltage-insensitive, Ca2+-dependent K+ current. Slow AHPs are a widespread phenomenon in mammalian (including human) neurons and are present in both peripheral and central nervous systems. Although, the molecular identity of ion channels responsible for common membrane potential mechanisms has been largely determined, the nature of the channels that underlie the sAHPs in neurons, both in the brain and in the periphery, remains unresolved. This short review discusses why there is no clear molecular candidate for sAHPs. |
Databáze: | OpenAIRE |
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