Effects of nicotine conditioning history on alcohol and methamphetamine self-administration in rats
| Autor: | Jennifer E. Murray, Brayden Fortino, Joyce Besheer, Mackenzie P. Callen, Scott T. Barrett, Rick A. Bevins, Brady M. Thompson, Christopher E. Larsen, Patrick A. Randall, Y. Wendy Huynh |
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| Rok vydání: | 2018 |
| Předmět: |
Drug
Male Nicotine media_common.quotation_subject Clinical Biochemistry Physiology Alcohol Self Administration Toxicology Affect (psychology) Biochemistry Article Methamphetamine 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 0302 clinical medicine Medicine Animals Rats Long-Evans Reinforcement Biological Psychiatry media_common Pharmacology Ethanol business.industry 030227 psychiatry Rats chemistry Conditioning Conditioning Operant Female business Self-administration 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Pharmacology, biochemistry, and behavior. 179 |
| ISSN: | 1873-5177 |
| Popis: | Background Smoking constitutes a significant public health risk. Alcohol and methamphetamine use disorders are also highly co-morbid with smoking, further increasing negative health outcomes. An important question in determining the underlying neurobiology of nicotine poly-drug use is understanding whether having a positive history with nicotine effects alters later drug-taking behavior. Methods The current experiments sought to elucidate whether having an appetitive nicotine conditioning history would affect later alcohol or methamphetamine self-administration. Adult male and female Long-Evans rats were first trained on a discriminated goal-tracking task in which the interoceptive effects of nicotine predicted sucrose reinforcement. As a control, pseudo-conditioned groups were included that had equated nicotine and sucrose experience. Rats were then shifted to either alcohol self-administration or methamphetamine self-administration. Results Nicotine conditioning history had no effect on acquisition or maintenance of alcohol self-administration in males or females. In contrast, an appetitive nicotine conditioning history decreased methamphetamine self-administration in female rats, but not males. Conclusions In female, but not male, rats, an appetitive conditioning history with nicotine decreases methamphetamine, but not alcohol, self-administration. This dissociation suggests that the effects may be due to a specific increase in the reinforcing value of methamphetamine. This may have implications for better understanding the progression of drug use from nicotine to methamphetamine. |
| Databáze: | OpenAIRE |
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