Synergistic interaction between dexamethasone and tramadol in a murine model of acute visceral pain
| Autor: | Hugo F. Miranda, Christian Dürsteler, Raquel Poveda, Anna Mases, Eulalia Planas, Margarita M. Puig |
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| Rok vydání: | 2007 |
| Předmět: |
Nausea
medicine.drug_class Analgesic Pain Pharmacology Models Biological Dexamethasone Mice medicine Animals Humans Antiemetic Pharmacology (medical) Glucocorticoids Tramadol Pain Measurement Dose-Response Relationship Drug business.industry Drug Synergism Visceral pain Drug interaction Analgesics Opioid Disease Models Animal Anesthesia Antiemetics Corticosteroid Female medicine.symptom business medicine.drug |
| Zdroj: | Fundamental & Clinical Pharmacology. 21:515-520 |
| ISSN: | 1472-8206 0767-3981 |
| DOI: | 10.1111/j.1472-8206.2007.00511.x |
| Popis: | Tramadol is effective in the management of mild to moderate postoperative pain, but its administration is associated with nausea and vomiting. Patients treated with tramadol, often receive dexamethasone as antiemetic. The aim of our investigation was to assess if the two drugs interact in a murine model of acute visceral pain. Using the acetic acid writhing test in mice, we assessed the antinociceptive effects of tramadol and dexamethasone (a glucocorticoid with antiemetic effect) administrated individually and in a 1 : 1 fixed ratio combination. Tramadol and dexamethasone induced a dose-dependent inhibition of the writhing response when administered individually, with ED(50) values of 2.9 [2.09-4.31, 95% confidence limit (CL)] mg/kg, and 0.13 (0.05-0.29, 95% CL) mg/kg, respectively. The ED(50) of the combination was 0.13 (0.01-0.29, 95% CL) mg/kg; the isobolographic and interaction index analysis revealed a synergistic interaction. The results suggest that the combination of tramadol and dexamethasone could be beneficial in the management of postoperative pain in humans. |
| Databáze: | OpenAIRE |
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