Synthesis of β-enamino acid and heteroaryl acetic acid derivatives by Pd-catalyzed carbonylation of α-chloroimines and 2-chloromethyl aza-heterocycles
| Autor: | Antonio Salomone, Martina Capua, Luigino Troisi, Serena Perrone, Giuseppe Cannazza |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Double bond 010405 organic chemistry Chemistry Organic Chemistry Single step Heteroaryl acetic acid 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Catalysis Arylacetic acids Pd-catalyzed carbonylation α-Chloroimines β-Enamino amides β-Enamino esters Drug Discovery3003 Pharmaceutical Science Drug Discovery Organic chemistry Carbonylation |
| Zdroj: | Tetrahedron Letters. 57:1421-1424 |
| ISSN: | 0040-4039 |
| Popis: | β-Enamino esters or amides can be synthesized in a single step by a carbonylative coupling of α-chloroimines with alcohols or amines under Pd-catalysis. The methodology has been also applied to the preparation of heteroaryl acetic acid derivatives starting from chloromethyl heteroaromatic rings containing a C N double bond. The in situ generation of a β-imino acylpalladium species has been proposed as a key step for the process. |
| Databáze: | OpenAIRE |
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