Magnetic resonance imaging techniques demonstrate soft tissue damage in the diabetic foot
| Autor: | W. Vennart, John E. Tooke, John E. Foster, P. D. Brash, P. Anthony |
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| Rok vydání: | 1999 |
| Předmět: |
Pathology
medicine.medical_specialty Diabetic neuropathy business.industry Endocrinology Diabetes and Metabolism Muscles Adipose tissue Anatomy Middle Aged medicine.disease Diabetic foot Magnetic Resonance Imaging Fat pad Diabetic Foot Vibration perception Endocrinology Atrophy Peripheral neuropathy Adipose Tissue Diabetes mellitus Internal Medicine Linear Models Medicine Humans business |
| Zdroj: | Diabetic medicine : a journal of the British Diabetic Association. 16(1) |
| ISSN: | 0742-3071 |
| Popis: | Summary Aims Our objective was to assess the qualitative soft tissue changes which occur in the diabetic neuropathic foot, which may predispose to ulceration, using a specific magnetic resonance imaging (MRI) contrast sequence, magnetization transfer (MT) which produces contrast based on exchange between water bound to macromolecules (e.g. collagen) and free water (e.g. extracellular fluid). Methods The first metatarsal head of 19 diabetic neuropathic subjects and 11 diabetic non-neuropathic controls was studied using a ‘targeted’ radiofrequency coil. Neuropathy was classified using vibration perception threshold (VPT) ( 25 V), cold threshold ( 4 °C) and Michigan neuropathy score ( 15). Peripheral vascular disease was excluded. Results were expressed as percentage of tissue MT activity in a cross-sectional area. At autopsy full thickness biopsies were taken from the plantar fat pad of 10 unrelated subjects with diabetic neuropathy. Results Healthy muscle displays high MT activity, whereas adipose tissue induces little activity. Muscle MT activity was considerably reduced (75 ± 20%, 30 ± 24%, P |
| Databáze: | OpenAIRE |
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