Adherence to COPD treatment in Turkey and Saudi Arabia: results of the ADCARE study
| Autor: | Mohammed Al Ghobain, I. Kivilcim Oguzulgen, Sarfraz Saleemi, Mehmet Polatli, Adam Doble, Fayaz Aziz, Luqman Tariq, Javed Khan, Abdelkader El Hasnaoui, Nurdan Kokturk |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Health Knowledge
Attitudes Practice Turkey Cross-sectional study Health Status Hospital Anxiety and Depression Scale Severity of Illness Index non-adherence Pulmonary Disease Chronic Obstructive 0302 clinical medicine Quality of life Risk Factors Surveys and Questionnaires Odds Ratio 030212 general & internal medicine Depression (differential diagnoses) MMAS-8 Original Research COPD Depression Age Factors CAT General Medicine Middle Aged Mental Health Treatment Outcome Educational Status geographic locations Adult medicine.medical_specialty 8-item Morisky Medication Adherence Scale EuroQol Five-Dimension questionnaire education Saudi Arabia International Journal of Chronic Obstructive Pulmonary Disease Medication Adherence Interviews as Topic 03 medical and health sciences EQ-5D Internal medicine Severity of illness parasitic diseases medicine Humans Chi-Square Distribution business.industry Odds ratio medicine.disease respiratory tract diseases Cross-Sectional Studies Logistic Models 030228 respiratory system Multivariate Analysis Quality of Life business COPD Assessment Test |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease |
| Popis: | Nurdan Kokturk,1 Mehmet Polatli,2 I Kivilcim Oguzulgen,1 Sarfraz Saleemi,3 Mohammed Al Ghobain,4 Javed Khan,5 Adam Doble,6 Luqman Tariq,7 Fayaz Aziz,7 Abdelkader El Hasnaoui7 1Department of Pulmonary Medicine, School of Medicine, Gazi University, Besevler, Turkey; 2Department of Pulmonary Medicine, School of Medicine, Adnan Menderes University, Aydin, Turkey; 3Section of Pulmonary Medicine, Department of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; 4Department of Medicine, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; 5Department of Medicine, King Fahd Armed Forces Hospital, Jeddah, Saudi Arabia; 6Foxymed, Paris, France; 7GlaxoSmithKline, Dubai, UAE Background: COPD affects millions of people worldwide. Poor treatment adherence contributes to increased symptom severity, morbidity and mortality. This study was designed to investigate adherence to COPD treatment in Turkey and Saudi Arabia. Methods: An observational, cross-sectional study in adult COPD patients in Turkey and Saudi Arabia. Through physician-led interviews, data were collected on sociodemographics and disease history, including the impact of COPD on health status using the COPD Assessment Test (CAT); quality of life, using the EuroQol Five-Dimension questionnaire (EQ-5D); and anxiety and depression using the Hospital Anxiety and Depression Scale (HADS). Treatment adherence was measured using the 8-item Morisky Medication Adherence Scale (MMAS-8). Multivariate logistic regression analysis examined the predictors of non-adherence and the impact of adherence on symptom severity. Results: Four hundred and five COPD patients participated: 199 in Turkey and 206 in Saudi Arabia. Overall, 49.2% reported low adherence (MMAS-8 15) compared to 58.4% reporting medium/high adherence (p=0.0008). Patients with low adherence reported a lower mean 3-level EQ-5D utility value (0.54±0.35) compared to those with medium/high adherence (0.64±0.30; p10 was associated with lower adherence (OR 2.50 [95% CI: 1.43–4.39] and 2.43 [95% CI: 1.39–4.25], respectively; p=0.0008). Being a high school/college graduate was associated with better adherence compared with no high school (OR 0.57 [95% CI: 0.33–0.98] and 0.38 [95% CI: 0.15–1.00], respectively; p=0.0310). After adjusting for age, gender, and country, a significant association between treatment adherence (MMAS-8 score ≥6) and lower disease impact (CAT ≤15) was observed (OR 0.56 [95% CI: 0.33–0.95]; p=0.0314). Conclusion: Adherence to COPD treatment is poor in Turkey and Saudi Arabia. Non-adherence to treatment is associated with higher disease impact and reduced quality of life. Depression, age, and level of education were independent determinants of adherence. Keywords: COPD, non-adherence, 8-item Morisky Medication Adherence Scale, MMAS-8, EuroQol Five-Dimension questionnaire, EQ-5D, COPD Assessment Test, CAT, Turkey, Saudi Arabia |
| Databáze: | OpenAIRE |
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