Thromboembolic risk in patients with high titre anticardiolipin and multiple antiphospholipid antibodies
| Autor: | Martine Le Comte, Lawrence Joseph, Erika Chang, Jeannine Kassis, Joyce Rauch, Carolyn Neville, Paul Fortin |
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| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Risk Autoantigens Article Autoimmune Diseases Cohort Studies immune system diseases Thromboembolism Humans Prospective Studies neoplasms Aged Glycoproteins Venous Thrombosis Hematology Middle Aged Antiphospholipid Syndrome Cross-Sectional Studies Immunoglobulin M beta 2-Glycoprotein I Antibodies Anticardiolipin Immunoglobulin G Lupus Coagulation Inhibitor Antibodies Antiphospholipid Female |
| Popis: | SummaryAsymptomatic antiphospholipid antibody (aPL) carriers with high risk for thrombosis may benefit from preventive anticoagulation.It was our objective to test whether the risk of thrombosis increases with: 1) increasing titres of anticardiolipin antibodies (aCL) after adjustment for other cardiovascular risk factors and 2) the number of aPL detected.In a cross-sectional study, blood was collected from clinics in two teaching hospitals. The study included 208 individuals suspected of having an aPL and 208 age- and sex-matched controls having blood drawn for a complete blood count.Clinical variables included history of previous arterial (ATE) or venous (VTE) thrombotic events, traditional risk factors for cardiovascular disease, and systemic lupus erythematosus (SLE). Laboratory variables included IgG/IgM aCL, lupus anticoagulant, and IgG/IgM anti-β2-glycoprotein I.Mean age was 46.5 years and 83% were female. Seventy-five of the 416 participants had > 1 aPL, and 69 had confirmed > 1 ATE or VTE. Family history was positive in 48% of participants, smoking in 28%, hypertension in 16%, diabetes in 6%, and SLE in 20%. A 10-unit increase in aCL IgG titre was associated with an odds ratio (OR) [95% CI] of 1.07 [1.01-1.13] for ATE and 1.06 [1.02 - 1.11] for VTE. The odds of a previous thrombosis increased with each additional aPL detected: 1.5 [0.93-2.3] for ATE and 1.7 [1.1-2.5] for VTE.These results indicate that increased titres of aCL and multiple aPL were associated with an increased risk of a previous thrombotic event. |
| Databáze: | OpenAIRE |
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