Pregnancy outcome in women with transfused beta-thalassemia in France
Autor: | Stanislas Nimubona, Giovanna Cannas, Jean-Antoine Ribeil, Isabelle Thuret, Sabine Jardel, Raoul Herbrecht, Frédéric Galactéros, Florence Lachenal, Marie-José Lucchini, Emilie Virot, Arnaud Hot, François Lionnet, Julie Machin |
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Rok vydání: | 2021 |
Předmět: |
Adult
medicine.medical_specialty Population Reproductive technology Pregnancy Humans Medicine education Retrospective Studies Full Term education.field_of_study Fetal Growth Retardation Cesarean Section business.industry Obstetrics Pregnancy Complications Hematologic beta-Thalassemia Infant Newborn Pregnancy Outcome Beta thalassemia Hematology General Medicine medicine.disease Gestational diabetes Cross-Sectional Studies Hemoglobinopathy Female Amenorrhea France medicine.symptom Erythrocyte Transfusion business |
Zdroj: | Annals of Hematology. 101:289-296 |
ISSN: | 1432-0584 0939-5555 |
DOI: | 10.1007/s00277-021-04697-4 |
Popis: | Because of chronic anemia, hypogonadotropic hypogonadism, and iron chelation, pregnancy in homozygous and heterozygous compound beta-thalassemia patients stays a challenge. Pregnancies of transfused beta-thalassemia women registered in the French National Registry, conducted between 1995 and 2015, are described. These pregnancies were compared with pregnancies in healthy women and to data previously published in the literature. Fifty-six pregnancies of 37 women were studied. There were 5 twin pregnancies. Assisted reproductive technologies (ART) were used in 9 pregnancies. Median term at delivery was 39 amenorrhea weeks, and median weight at birth was 2780 g. Cesarean section was performed in 53.6% of the pregnancies. There were 6 thromboembolic events, 6 serious infections, 6 pregnancy-induced hypertensions (PIH), 6 intrauterine growth retardations (IUGR), 5 severe hemorrhages, 4 gestational diabetes, 3 alloimmunizations, 2 heart diseases, and 1 pre-eclampsia. There were 5 infections and 4 osteoporosis in the first year of post-partum. ART and cesarean sections were more often used in the beta-thalassemia group, compared to control subjects. Thromboembolic events, PIH, hemorrhage at delivery, and IUGR were more frequent in the beta-thalassemia group. Time to delivery was not different, but infant weight at birth was significantly smaller in the beta-thalassemia group. In the post-partum period, global maternal complications were more frequent in the beta-thalassemia group. Pregnancy in transfused beta-thalassemia women is safe with rare obstetrical and fetal complications. Cesarean section remains often chosen, and infant weight at birth remains smaller than that in the general population, despite delivery at full term. |
Databáze: | OpenAIRE |
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