Specific Features of Patients With Inflammatory Bowel Disease and Primary Sclerosing Cholangitis
| Autor: | Athanasios Kavvadias, Konstantinos H. Katsanos, Fotios S. Fousekis, Dimitrios K. Christodoulou, Alexandros Skamnelos, Vasileios Theopistos, Ioannis V. Mitselos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Crohn’s disease
medicine.medical_specialty endocrine system diseases Colorectal cancer medicine.medical_treatment Review Liver transplantation Inflammatory bowel disease Gastroenterology digestive system Primary sclerosing cholangitis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Risk factor Crohn's disease business.industry digestive oral and skin physiology General Medicine medicine.disease Ulcerative colitis digestive system diseases 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology business Progressive disease |
| Zdroj: | Journal of Clinical Medicine Research |
| ISSN: | 1918-3011 1918-3003 |
| Popis: | Primary sclerosing cholangitis (PSC) is a chronic and progressive disease of the biliary tract. PSC is strongly associated with inflammatory bowel disease (IBD), mainly with ulcerative colitis, and most PSC patients have underlying IBD. The pathophysiological interactions between IBD and PSC are unclear, although it seems that the patients with IBD and PSC have a distinct phenotype. IBD with coexisting PSC is more extensive and is characterized by milder activity compared to IBD alone. The coexistence of PSC increases the risk for colorectal cancer in IBD patients and lifelong annual surveillance colonoscopy is recommended. Also, liver transplantation (LT) for PSC may affect the course of IBD. In addition, the management of IBD after LT includes many specific problems. On the other hand, the effect of IBD on the natural history of PSC appears to be milder. However, IBD may increase the risk of postsurgical complications after LT and is a risk factor for recurrent PSC after LT. Overall, the coexistence of IBD with PSC changes the management, natural history and prognosis of both diseases. |
| Databáze: | OpenAIRE |
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