846. Postnatally Acquired Zika Virus (ZIKV) Infection in Infants and Young Children in Guatemala: Serologic and Neurodevelopmental (ND) Evaluation

Autor:	Flor M Munoz, Amy Connery, Muktha S Natrajan, Jesse Waggoner, Molly Lamb, Daniel Olson, Alejandra Paniagua-Avila, Desiree Bauer, Evan J Anderson, Mark Mulligan, Mirella Calvimontes, Guillermo Bolanos, Andrea Holliday, Wendy Keitel, Hana El Sahly, Kay Tomashek, Edwin J Asturias
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	myalgia biology business.industry medicine.disease biology.organism_classification Virology Dengue fever law.invention Serology Zika virus Flavivirus Abstracts Infectious Diseases Oncology Oral Abstracts law medicine ZikV Infection Flavivirus Infections medicine.symptom business Polymerase chain reaction
Zdroj:	Open Forum Infectious Diseases
ISSN:	2328-8957
Popis:	Background Diagnosing ZIKV infection in children in dengue (DENV) endemic regions is challenging. The kinetics and effects of maternal Ab on infant infection responses remain unknown, as do the ND effects of ZIKV acquired in early life. Methods This is a population-based prospective cohort study in infant–mother pairs and children Results In total, 1,371 subjects (374 children 1–5 years, 500 infants, 497 mothers) were enrolled from June 2017 to July 2018. Among 1,335 evaluable subjects, 7.6% (101) had serologic evidence of recent ZIKV infection (NAb >500 or >100 and DENV-neg); 13.2% (176) were DENV-pos only; 44.8% (598) were ZIKV-neg (NAb15 − Conclusion Serologic evidence of recent ZIKV infection, but no acute ZIKV, was documented in young children in Guatemala. Infant seroreactivity derives from prior maternal infection and DENV cross-reactivity. Observed substantial differences in ND scores between infants and children 1–5 years challenge the ability to isolate the potential effects of ZIKV infection in early life. NIAID Contract HHSN272201300015I Task Order HHSN27200013. FMM and EJA Co-PIs. Disclosures Flor M. Munoz, MD, Biocryst: Grant/Research Support; CDC: Research Grant; Moderna: Other Financial or Material Support, Safety Monitoring Board Member/Chair; NIH: Research Grant; Novavax: Research Grant; UP to Date: Author and Editor: Royalties, Other Financial or Material Support.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a79883879e2cecf1ff8183f4626d041 http://europepmc.org/articles/PMC6809372 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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