Preparation and Characterization of Lanthanum Carbonate Octahydrate for the Treatment of Hyperphosphatemia
| Autor: | Xiren He, Ming Huang, Yan Sun, Qin Li, Fengshan Zhou, Xing Zhao, He Anqi, Yang Zhanlan, Ran Guo, Jinguang Wu, Xin Zhang, Fang Ye, Ying Zhang, Yizhuang Xu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
inorganic chemicals
endocrine system animal structures Article Subject Inorganic chemistry chemistry.chemical_element Phosphate Chloride digestive system Atomic and Molecular Physics and Optics Complexometric titration Analytical Chemistry chemistry.chemical_compound Lanthanum carbonate chemistry Elemental analysis medicine Lanthanum Hydroxide lcsh:QC350-467 Fourier transform infrared spectroscopy Spectroscopy lcsh:Optics. Light Nuclear chemistry medicine.drug |
| Zdroj: | Journal of Spectroscopy, Vol 2013 (2013) |
| ISSN: | 2314-4939 2314-4920 |
| Popis: | We proposed a new approach to prepare lanthanum carbonate via reactions between lanthanum chloride and NaHCO3. In the reaction, small amount of NaHCO3solution was firstly added to the acidic lanthanum chloride solution to generate lanthanum carbonate nuclei and then NaHCO3is added to the lanthanum chloride at a constant speed. This approach makes both precipitation reaction and neutralization reaction take place simultaneously. Consequently, lanthanum carbonate is produced at low pH environment (pH below 4.0) so that the risk of generating lanthanum carbonate hydroxide is reduced. The product of the above reaction is validated by EDTA titration, elemental analysis, and XRD characterization. In addition, we established a FTIR spectroscopic method to identify La(OH)CO3from La2(CO3)2·8H2O. Lanthanum carbonate exhibits considerable ability to bind phosphate. |
| Databáze: | OpenAIRE |
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