Assessment of functional nanomaterials in medical applications: can time mend public and occupational health risks related to the products’ fate?
| Autor: | Cécile Pagnoux, Martin Morgeneyer, Alexandra Aubry, Christophe Bressot, Olivier Aguerre-Chariol |
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| Přispěvatelé: | Institut National de l'Environnement Industriel et des Risques (INERIS), Centre d'Immunologie et des Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), IRCER - Axe 1 : procédés céramiques (IRCER-AXE1), Institut de Recherche sur les CERamiques (IRCER), Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Transformation Intégrée de la Matière Renouvelable (TIMR), Université de Technologie de Compiègne (UTC), DERORY, BEATRICE, Centre d'Immunologie et de Maladies Infectieuses (CIMI), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie du CNRS (INC)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2018 |
| Předmět: |
Time Factors
Materials science Health Toxicology and Mutagenesis environmental exposure Metal Nanoparticles Nanotechnology 02 engineering and technology 010501 environmental sciences engineering.material Toxicology Risk Assessment 01 natural sciences Nanomaterials Coating Anti-bacterial agents Occupational Exposure Floors and Floorcoverings Humans [SDV.EE.SANT] Life Sciences [q-bio]/Ecology environment/Health Public and Occupational Health [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials 0105 earth and related environmental sciences Titanium [SDV.EE.SANT]Life Sciences [q-bio]/Ecology environment/Health Photolysis Nano-sized titanium dioxide Environmental exposure 021001 nanoscience & nanotechnology Product lifetime [SDV.IB.BIO] Life Sciences [q-bio]/Bioengineering/Biomaterials [SDV.TOX] Life Sciences [q-bio]/Toxicology Air Pollution Indoor [SDV.TOX]Life Sciences [q-bio]/Toxicology Healthcare settings material aging engineering 0210 nano-technology Time of use aerosols |
| Zdroj: | Journal of Toxicology and Environmental Health, Part A: Current Issues Journal of Toxicology and Environmental Health, Part A: Current Issues, 2018, 81 (19), pp.957-973. ⟨10.1080/15287394.2018.1477271⟩ Journal of Toxicology and Environmental Health, Part A: Current Issues, Taylor & Francis, 2018, 81 (19), pp.957-973. ⟨10.1080/15287394.2018.1477271⟩ |
| ISSN: | 1087-2620 1528-7394 |
| Popis: | International audience; Surface coatings are one promising option to prevent bacterial adhesion and biofilm formation given the prevalence of antibiotic resistant bacterial strains. Titanium dioxide (TiO2) is presently considered to be the only photocatalytic material suitable for commercial use, although the toxicity risks of TiO2, particularly in its nanoparticulate form, have not been fully addressed. The aim of this study was to determine release of nanoparticles (NPs) from functional materials for medical applications and their aerosol formation. Further, the fate of the material with respect to its product lifetime was investigated. The present study examined the risk of NP exposure since released submicronic and inhalable manufactured nano-objects, their agglomeraates or aggregates containing Ti were detected. The coating of the material magnifies its emission levels when comparing the obtained product properties to those of an uncoated sample. The evolution of release tendecy with the material’s time of use shows that release does not vanish upon continuous material losses induced by the release, thus the risk does not diminish with time. Consequently, this nanomaterial TiO2 needs to be avoided in healthcare settings, or, alternatively, new TiO2-deposition techniques are required to be developed. |
| Databáze: | OpenAIRE |
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