Hearing Loss With Congenital Cytomegalovirus Infection
| Autor: | Elke Lichtert, Ronald Buyl, Frans Gordts, Fleur Anne Camfferman, Denis Pierard, Yannick De Brucker, Leonardo Gucciardo, Ina Foulon, Katia Verbruggen |
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| Přispěvatelé: | Surgical clinical sciences, Microbiology and Infection Control, Radiology, Faculty of Medicine and Pharmacy, Biostatistics and medical informatics, Public Health Sciences, Ear, nose & throat, Supporting clinical sciences, Clinical Biology, Growth and Development, Neonatology, Mother and Child, Obstetrics |
| Rok vydání: | 2020 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Hearing loss Congenital cytomegalovirus infection Asymptomatic 03 medical and health sciences 0302 clinical medicine Neonatal Screening Pregnancy 030225 pediatrics otorhinolaryngologic diseases medicine Humans Prospective Studies Prospective cohort study Hearing Loss Children Medicine(all) business.industry Infant Newborn Infant Obstetrics and Gynecology Gestational age Sequela General Medicine medicine.disease First trimester cCMV Child Preschool Prenatal Exposure Delayed Effects Pediatrics Perinatology and Child Health Cytomegalovirus Infections Female Sensorineural hearing loss medicine.symptom business Congenital Cytomegalovirus Infection Follow-Up Studies |
| Zdroj: | Obstetrical & Gynecological Survey. 75:5-7 |
| ISSN: | 1533-9866 0029-7828 |
| Popis: | OBJECTIVE:In this study, we determined the prevalence of hearing loss in 157 children with proven congenital cytomegalovirus (cCMV) infection. We looked at possible risk determinants for developing hearing loss and proposed recommendations for screening and follow-up in the newborn.METHODS:In a prospective 22-year study, 157 children with proven cCMV infection were evaluated for sensorineural hearing loss (SNHL). The development of SNHL was correlated with the type of maternal infection (primary versus nonprimary), the gestational age of maternal primary infection, imaging findings at birth, and the presence of symptomatic or asymptomatic infection in the newborn.RESULTS:Of all children, 12.7% had SNHL, and 5.7% needed hearing amplification because of SNHL. Improvement, progression, and fluctuations of hearing thresholds were seen in 45%, 53.8%, and 5.7% of the children, respectively. Hearing loss was more common in the case of a symptomatic infection at birth (P = .017), after a maternal primary infection in the first trimester of pregnancy (P = .029), and in the presence of abnormalities on a neonatal brain ultrasound and/or MRI (P < .001).CONCLUSIONSNHL is a common sequela in children with cCMV infection. Risk factors for SNHL were primary maternal infections before the 14th week of pregnancy, the presence of a disseminated infection at birth, and imaging abnormalities in the newborn. These children may benefit from a more thorough investigation for SNHL than children who do not present with those risk factors. |
| Databáze: | OpenAIRE |
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