Mechanochemical Signaling of the Extracellular Matrix in Epithelial-Mesenchymal Transition
| Autor: | Seth H. Weinberg, Lewis E. Scott, Christopher A. Lemmon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cell signaling Review Extracellular matrix Cell and Developmental Biology 03 medical and health sciences Mechanobiology 0302 clinical medicine Intracellular signaling pathways Epithelial–mesenchymal transition lcsh:QH301-705.5 Chemistry Transdifferentiation Mesenchymal stem cell Cell Biology mechanobiology extracellular matrix (ECM) Cell biology Epithelial phenotype epithelial-mesenchymal transition (EMT) 030104 developmental biology lcsh:Biology (General) 030220 oncology & carcinogenesis embryonic structures cellular signaling epithelial phenotype Developmental Biology |
| Zdroj: | Frontiers in Cell and Developmental Biology, Vol 7 (2019) Frontiers in Cell and Developmental Biology |
| DOI: | 10.3389/fcell.2019.00135/full |
| Popis: | Epithelial-Mesenchymal Transition (EMT) is a critical process in embryonic development in which epithelial cells undergo a transdifferentiation into mesenchymal cells. This process is essential for tissue patterning and organization, and it has also been implicated in a wide array of pathologies. While the intracellular signaling pathways that regulate EMT are well-understood, there is increasing evidence that the mechanical properties and composition of the extracellular matrix (ECM) also play a key role in regulating EMT. In turn, EMT drives changes in the mechanics and composition of the ECM, creating a feedback loop that is tightly regulated in healthy tissues, but is often dysregulated in disease. Here we present a review that summarizes our understanding of how ECM mechanics and composition regulate EMT, and how in turn EMT alters ECM mechanics and composition. |
| Databáze: | OpenAIRE |
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