A novel rapid throughput phototolerance screen in mice

Autor:	E.Themis Joannides, Josephine C. Sesnie, Carl L. Heifetz, Thomas E. Malta, Martin A. Shapiro, Julie A. Dever
Rok vydání:	1996
Předmět:	Pharmacology Drug Evaluation Preclinical Mice Inbred Strains Computational biology Quinolones Biology Toxicology Skin Diseases Combinatorial chemistry Mice Drug development In vivo Animals Female Throughput (business) Dermatitis Phototoxic
Zdroj:	Journal of Pharmacological and Toxicological Methods. 36:185-187
ISSN:	1056-8719
DOI:	10.1016/s1056-8719(96)00109-8
Popis:	A relatively simple, rapid throughput phototolerance screen in small animals would be very useful in early drug development. It could prioritize or select potential lead compounds from among a number of analogs with similar biological activities. This study describes an in vivo mouse phototolerance screen established for that purpose. It also reports phototolerance data with standard reference drugs obtained using this screen.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7518856834afb152c9aa75b02c0ba0 https://doi.org/10.1016/s1056-8719(96)00109-8 Zobrazit plný text záznamu Full Text from ScienceDirect