Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers
| Autor: | Karla Freire Rezende, Danilo J.P.G. Rocha, Silvia Ines Sardi, Rejane Hughes Carvalho, João Santana da Silva, Luis G.C. Pacheco, Daniel M. Altmann, João Victor Gomes Santos, Camilla Natália Oliveira Santos, Lucas Sousa Magalhães, Juliana Cardoso Alves, Emília Maria Medeiros de Andrade Belitardo, Marília Marques Aquino, Maria Luiza Doria Almeida, Cliomar Alves dos Santos, Gubio Soares Campos, Rafaela Mota de Jesus, Letícia Adrielle dos Santos, Ianaline Lima Santos, Eric R.G.R. Aguiar, Amélia Ribeiro de Jesus, Pedro Germano de Góis Filho, Rosemary J. Boyton, João Paulo Pereira de Almeida, Douglas Siqueira Santos, Roque P. Almeida, Ana Maria Fantini Silva |
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| Přispěvatelé: | Medical Research Council (MRC) |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Health Personnel 030106 microbiology Disease Severity of Illness Index Microbiology Antibodies Virus 03 medical and health sciences 0302 clinical medicine Recurrence Internal medicine Severity of illness medicine Humans 030212 general & internal medicine Letter to the Editor Blood type First episode SARS-CoV-2 business.industry Case-control study COVID-19 1103 Clinical Sciences Chronic infection Infectious Diseases Case-Control Studies Reinfection ÍNDICE DE GRAVIDADE DA DOENÇA Female Observational study business Brazil |
| Zdroj: | Journal of Infection The Journal of Infection Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 0163-4453 |
| DOI: | 10.1016/j.jinf.2021.01.020 |
| Popis: | BACKGROUND: There is growing concern about individuals reported to suffer repeat COVID-19 disease episodes, these in a small number of cases characterised as de novo infections with distinct sequences, indicative of insufficient protective immunity even in the short term. METHODS: Observational case series and case-control studies reporting 33 cases of recurrent, symptomatic, qRT-PCR positive COVID-19. Recurrent disease was defined as symptomatic recurrence after symptom-free clinical recovery, with release from isolation >14 days from the beginning of symptoms confirmed by qRT-PCR. The case control study-design compared this group of patients with a control group of 62 patients randomly selected from the same COVID-19 database. RESULTS: Of 33 recurrent COVID-19 patients, 26 were female and 30 were HCW. Mean time to recurrence was 50.5 days which was associated with being a HCW (OR 36.4 (p |
| Databáze: | OpenAIRE |
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