Ghrelin, obestatin and the ghrelin/obestatin ratio as potential mediators for food intake among obese children: a case control study
| Autor: | Nayera E. Hassan, Hanaa H. Ahmed, Ghada M. Anwar, Rokia A El-Banna, Sahar A. El-Masry, Ayat N Kamal, Gamal Samy Aly, Nihad H. Ahmed, Reham S. Tarkan |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Pediatric Obesity Food intake medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Energy homeostasis Eating 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Humans 030212 general & internal medicine Child Appetite Regulation business.industry digestive oral and skin physiology Case-control study Obestatin Prognosis medicine.disease Obesity Ghrelin Cross-Sectional Studies Case-Control Studies Pediatrics Perinatology and Child Health Appetite stimulating Female business Biomarkers Follow-Up Studies Hormone |
| Zdroj: | Journal of Pediatric Endocrinology and Metabolism. 33:199-204 |
| ISSN: | 2191-0251 0334-018X |
| DOI: | 10.1515/jpem-2019-0286 |
| Popis: | Background Ghrelin and obestatin are two gastric hormones encoded by the same preproghrelin gene that convey information concerning nutritional status to the central nervous system. Ghrelin has been considered as an appetite stimulating peptide that has a role in the regulation of energy homeostasis. Obestatin has been described for its appetite suppressing effects opposing ghrelin’s effect on food intake. The study aimed to evaluate ghrelin, obestatin and the ghrelin/obestatin ratio in obese children compared to non-obese and correlate them to food macronutrients intake. Methods This study is a cross-sectional case control study comprising 60 obese children, in addition to 31 age- and sex-matched controls. All children were subjected to clinical examination, anthropometric assessment, and a 3-day 24-h dietary recall. Fasting serum ghrelin and obestatin levels were evaluated, the ghrelin/obestatin ratio was calculated and they were correlated to macronutrients intake. Results Obese children had significantly lower serum fasting levels of ghrelin, obestatin and the ghrelin/obestatin ratio than the control group. The mean intake of total energy and macronutrients was significantly higher in obese children. Ghrelin showed positive correlation with total energy and fat intake in the obese group. Obestatin had positive correlations with total energy and fat intake while the ghrelin/obestatin ratio had a negative correlation with the total energy intake in the control group. Conclusions Ghrelin, obestatin and the ghrelin/obestatin ratio were significantly lower in obese children and significantly associated with their total energy intake. Disturbed ghrelin to obestatin balance may have a role in the etiology and pathophysiology of obesity. |
| Databáze: | OpenAIRE |
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