Immune Modulation and Treatment of Human Papilloma Virus-Related Warts with Energetics of Living Systems Acupuncture
| Autor: | Jacob Pitcovski, Malka Hochberg, Raia Goona, Rom Brustin, Bilha Kreisberg, Sari Murad, Tal Geffen, Martine Toledano |
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| Rok vydání: | 2017 |
| Předmět: |
Human papilloma virus
medicine.medical_specialty business.industry virus diseases Interleukin Original Articles Placebo Gastroenterology Virus Lesion 03 medical and health sciences 0302 clinical medicine Immune system Complementary and alternative medicine 030220 oncology & carcinogenesis Internal medicine Immunology medicine Acupuncture Tumor necrosis factor alpha medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Medical Acupuncture. 29:145-154 |
| ISSN: | 1933-6594 1933-6586 |
| Popis: | Background: Cutaneous warts are small skin lesions formed as a result of infection by the human papilloma virus (HPV). In the lesion, viral manipulation creates a microenvironment that favors virus survival and reproduction. Most lesions eventually regress, probably as a result of a Th1-mediated immune response. However, some warts fail to regress and become persistent. Objective: The efficacy of treatment of persistent HPV-caused warts with Energetics of Living Systems acupuncture and monitored immune system involvement was tested. Methods: Eighteen patients with persistent warts were recruited for the study; 9 received acupuncture treatment and 9 received placebo. Each patient was treated 4 times. Results: Clinical success was defined as total clearance of all lesions with no recurrence for 3 months. In the treatment group, clinical success was 36.6% versus 0% in the placebo group. In the treatment group, the level of interleukin (IL)-10 decreased. In a comparison of patients with cleared warts and overall patients with nonresponding warts, different expression levels of IL-8, IL-10, tumor necrosis factor-α, IL-6, and interferon-γ were found, although these differences were not always statistically significant. Trends of differences (not significant) were observed in leukocyte levels. Acupuncture eliminated persistent warts in some of the patients, along with inducing changes in immunologic parameters. Conclusions: Taking the clinical and immunologic outcomes together, clearance of persistent warts following acupuncture might be due to a shift toward a Th1 immune response, or an anti-inflammatory effect against the lesion-induced microenvironment. |
| Databáze: | OpenAIRE |
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