Occupational exposure to formaldehyde and biological monitoring of Research Institute workers
| Autor: | Lucia Maiorana, Donatella Ugolini, Claudia Bolognesi, Marcello Ceppi, Tiziana Schilirò, Roberto Bono, Mauro Pala, Paola Bigatti, Daniela Vecchio, Fabio Rizzo, Giorgio Gilli |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Cancer Research Laboratory personnel Serum albumin Formaldehyde Physiology Air Pollutants Occupational Micronuclei Chromosome aberration Biological markers Occupational exposure Sister chromatid exchanges Human serum albumin conjugate Smoking Fixatives chemistry.chemical_compound Humans Chromosome Aberrations biology Serum Albumin Bovine Middle Aged Research Personnel Work environment Peripheral blood Oncology chemistry Immunology Micronucleus test biology.protein Biomarker (medicine) Female Sister Chromatid Exchange Biomarkers |
| Popis: | Aim : The aim of this study was to verify the presence of a relationship between formaldehyde exposure in the work environment with biological markers of exposure and of effect. Methods : Exposure to formaldehyde (FA) of 36 workers in different laboratories of a Cancer Research Institute and biomarkers of exposure, such as formaldehyde human serum albumin conjugate (FA-HSA) and biomarkers of effect, such as chromosome aberration (CA), micronuclei (MN) and sister chromatid exchanges (SCEs) were measured in peripheral blood lymphocytes of the same workers. Results : Individual FA levels of exposure ranged from 4.9μg/m 3 to 268.7μg/m 3 . Subjects with high FA exposure showed a significant increase of the biomarker of exposure FA-HSA, but biomarkers of effect did not show any significant differences. Conclusions : A significant relationship was observed between occupational exposure to FA and a biological marker of exposure (FA-HSA). The markers of effect used (CA, MN and SCE) failed to indicate the presence of genetic damage. |
| Databáze: | OpenAIRE |
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