Blunted neuroendocrine stress reactivity in young women with eating disorders
| Autor: | Silja Vocks, Oliver T. Wolf, Stephan Herpertz, Jutta M. Wolf, Serkan Het, Philipp Hammelstein |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Hypothalamo-Hypophyseal System Anorexia Nervosa Adolescent Hydrocortisone media_common.quotation_subject Pituitary-Adrenal System medicine.disease_cause behavioral disciplines and activities Fight-or-flight response Young Adult Heart Rate mental disorders medicine Psychological stress Humans In patient Psychiatry Bulimia Nervosa Saliva media_common Bulimia nervosa Appetite medicine.disease Psychiatry and Mental health Clinical Psychology Eating disorders Anorexia nervosa (differential diagnoses) Female alpha-Amylases Stress reactivity Psychology Stress Psychological |
| Zdroj: | Journal of psychosomatic research. 78(3) |
| ISSN: | 1879-1360 |
| Popis: | Stress is known to influence risk and progression of eating disorders (EDs). However, studies investigating physiological and psychological stress responses under laboratory conditions in patients with Anorexia nervosa or Bulimia nervosa are scarce and often produce conflicting findings. We therefore aimed to compare the neuroendocrine and affective stress response in ED inpatients and healthy controls.Twenty-eight female inpatients with Anorexia or Bulimia nervosa and 26 healthy women were exposed to the Trier Social Stress Test (TSST). Salivary cortisol and alpha-amylase (sAA) levels were assessed before as well as repeatedly after stress exposure, while heart rate and heart rate variability were determined before and during the TSST. Negative affective state was assessed at baseline and post-TSST.Compared to healthy controls, ED patients showed blunted cortisol stress responses combined with overall attenuated sAA levels. The latter was reflected in generally enhanced parasympathetic activity indicated by lower heart rate and stronger high-frequency heart rate variability throughout the TSST. Although patients reported more negative affect overall, they did not differ in their affective stress response.In summary, patients suffering from eating disorders show a blunted HPA axis reactivity to stress exposure and a generally reduced sympathetic/exaggerated parasympathetic nervous system activity. This combination may contribute to elevated health risks seen in eating disorder patients, such as enhanced inflammatory activity, and thus provide insight into the underlying stress-related mechanisms. |
| Databáze: | OpenAIRE |
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