Ascitic fluid drainage using a peritoneal dialysis catheter to prevent and treat multi-organ dysfunction in veno-occlusive disease in children undergoing hematopoietic stem cell transplantation
| Autor: | Mohan Shenoy, Denise Bonney, Malcolm Lewis, Robert Wynn, Vijal Parmar |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Catheters Transplantation Conditioning medicine.medical_treatment Hepatic Veno-Occlusive Disease Disease Hematopoietic stem cell transplantation Peritoneal dialysis 03 medical and health sciences 0302 clinical medicine medicine Peritoneal dialysis catheter Ascitic Fluid Humans Chemotherapy business.industry Acute kidney injury Hematopoietic Stem Cell Transplantation Ascites Infant Hematology medicine.disease Surgery surgical procedures operative 030104 developmental biology Oncology Pediatrics Perinatology and Child Health Drainage 030211 gastroenterology & hepatology Veno-Occlusive Disease Female business Complication Peritoneal Dialysis |
| Zdroj: | Pediatric bloodcancer. 64(9) |
| ISSN: | 1545-5017 |
| Popis: | Veno-occlusive disease (VOD), or sinusoidal obstruction syndrome, is a well-recognised, serious complication associated with the chemotherapy conditioning therapy used in hematopoietic stem cell transplantation (HSCT). Fluid management is typically challenging in children with this condition. We describe effective early use of peritoneal dialysis catheters to drain extravascular, intra-abdominal fluid in children with VOD, allowing intravascular fluid administration to preserve renal perfusion and function, preventing multi-organ dysfunction. All but one of the children are long-term survivors, both of their significant VOD and their HSCT. The child that did not survive died from their underlying metabolic illness, not VOD. |
| Databáze: | OpenAIRE |
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