Oral prostaglandin E2 for labor induction in high-risk pregnancy
| Autor: | Kay Cox, Peggy J. Whalley, James D. Strong, F. Gary Cunningham, John C. Hauth |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Adult
Risk Nausea medicine.medical_treatment Bishop score Administration Oral Physiology Oxytocin Pregnancy Humans Medicine Labor Induced Prostaglandin E2 Fetus Cesarean Section business.industry Prostaglandins E Infant Newborn Obstetrics and Gynecology Delivery Obstetric Obstetric Labor Complications Pregnancy Complications Labor induction Anesthesia Hypertension Vomiting Female medicine.symptom business medicine.drug Prostaglandin E |
| Zdroj: | American Journal of Obstetrics and Gynecology. 125:881-888 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/0002-9378(76)90483-x |
| Popis: | Oral prostaglandin E 2 (PGE 2 ) was used alone or synergistically with intravenous oxytocin to induce labor in 84 women whose pregnancies were at high risk. A control group of 84 similar high-risk pregnancies where labor was induced with intravenous oxytocin alone was studied to compare the safety and efficacy of the two regimens. Oral PGE 2 administration, combined with the synergistic effect of intravenous oxytocin, is safe for induction of labor in gravid women whose fetuses are at risk. Uterine polysystole, which is potentially dangerous, especially to the high-risk fetus, was not commonly encountered and only once was associated with transient fetal bradycardia. Uterine hypertonus was not encountered with PGE 2 ; however, it did occur with oxytocin stimulation. Nausea and vomiting occurred in one third of the women treated with PGE 2 but were well tolerated and required discontinuation of the drug in only one instance. There was no apparent advantage of using the combination PGE 2 regimen in patients whose cervices were more favorable for induction of labor (Bishop score, 5 to 9). However, oral PGE 2 , used either alone or synergistically with oxytocin, appears twice as effective in inducing labor than was oxytocin alone in women in whom labor was considered to be "difficult to induce" (Bishop score, 0 to 4). |
| Databáze: | OpenAIRE |
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