Hormonal imbalance and alterations in testicular morphology induced by chronic ingestion of ethanol
| Autor: | B R Willis, Stan A. Beyler, Christine Oswald, Jakkidi M. Reddy, Robert A. Anderson, Lourens J.D. Zaneveld |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Physical dependence Biology Biochemistry Desquamation Mice chemistry.chemical_compound Human fertilization Internal medicine Testis medicine Animals Humans Testosterone Adverse effect Pharmacology Ethanol In vitro fertilisation Hormones Diet Substance Withdrawal Syndrome Mice Inbred C57BL Alcoholism Fertility Endocrinology chemistry Fertilization medicine.symptom Hormone |
| Zdroj: | Biochemical Pharmacology. 29:1409-1419 |
| ISSN: | 0006-2952 |
| DOI: | 10.1016/0006-2952(80)90437-2 |
| Popis: | Physical correlates of chronic ethanol consumption and measures of in vitro fertilization were examined in male C57B1 mice after a treatment period of 34 days with a total liquid nutriment diet which contained 5%/95% (v/v) ethanol. This diet represented relatively low levels of ethanol ingestion by the C57B1 mouse, as evidenced by the low peak levels of blood ethanol (160 mg/100 ml), the lack of behavioral signs of intoxication during treatment, and the absence of overt signs of physical dependence after withdrawal from the ethanol-containing diet. Plasma testosterone levels of experimental animals were depressed during the treatment period, as compared to testosterone levels of pair-fed controls. No evidence of hepatic injury was observed following the treatment period. Although fertility, as measured by the ability of spermatozoa to penetrate mouse ova in vitro , was unaffected by the chronic ethanol treatment, signs of testicular dysfunction were evident. Abnormal testicular morphology included disruption of the basement membranes of the seminiferous tubules, decreased tubular diameter, and desquamation of immature germ cells into the lumina of the tubules. The present study provides convincing evidence of the adverse effects upon male reproductive functions of relatively low levels of ethanol, when administered chronically, under controlled conditions. |
| Databáze: | OpenAIRE |
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